Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 2/20 | 0.45 |
| ▸ | CTSL | P07711 | 1/20 | 0.43 |
| ▸ | CTSS | P25774 | 1/20 | 0.43 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | GRM5 | P41594 | 1/20 | 0.40 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5792274 | 0.90 | CTSK (0.43) | CTSKCTSS | |
| SCHEMBL8268811 | 0.86 | TAS1R3 (0.40) | CTSKCTSLCTSSNPC1RAB9A | |
| SCHEMBL8270702 | 0.86 | NPC1 (0.46) | CTSKCTSLCTSSNPC1RAB9A | |
| Trifluoroacetic Acid SCHEMBL5794693 | 0.83 | TSHR (0.38) | CTSKCTSLCTSSABCB1NPC1 | |
| SCHEMBL5790636 | 0.82 | CTSK (0.44) | CTSKCTSLCTSSFGFR4 | |
| SCHEMBL8268817 | 0.80 | CTSK (0.43) | CTSKCTSLCTSSNPC1RAB9A | |
| SCHEMBL5793789 | 0.79 | LMNA (0.43) | CTSKCTSLCTSSNPC1RAB9A | |
| SCHEMBL5793805 | 0.77 | CTSK (0.52) | CTSKCTSLCTSSFGFR4 | |
| SCHEMBL5790947 | 0.77 | MCHR1 (0.52) | CTSKNPC1RAB9AMEN1KMT2A | |
| SCHEMBL8269394 | 0.75 | CTSL (0.45) | CTSKCTSLCTSSNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006027211-A1 | 2,4-SUBSTITUTED PYRIMIDINES AS CYSTEINE PROTEASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2006-03-16 | — | — | WO | claimed |
| WO-2006027211-A1 | 2,4-SUBSTITUTED PYRIMIDINES AS CYSTEINE PROTEASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2006-03-16 | — | — | WO | disclosed |