Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | CTSK | P43235 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | DDX3X | O00571 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.33 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 2/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.32 |
| ▸ | XBP1 | P17861 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8270680 | 0.94 | RAB9A (0.38) | RECQLNPC1RAB9ASMN1; SMN2CTSK | |
| Trifluoroacetic Acid SCHEMBL5791991 | 0.92 | FPR2 (0.40) | MEN1KMT2AMAPTIDO1FPR2 | |
| Trifluoroacetic Acid SCHEMBL5792578 | 0.90 | FPR2 (0.38) | NPC1RAB9ASMN1; SMN2TP53MEN1 | |
| Trifluoroacetic Acid SCHEMBL5793803 | 0.90 | NPC1 (0.41) | NPC1RAB9ASMN1; SMN2CTSKTP53 | |
| SCHEMBL8269995 | 0.88 | FPR2 (0.42) | MEN1KMT2AIDO1FPR2 | |
| Trifluoroacetic Acid SCHEMBL5794344 | 0.87 | CTSL (0.43) | SMN1; SMN2CTSKFGFR4HTTIDO1 | |
| Trifluoroacetic Acid SCHEMBL5791505 | 0.86 | LMNA (0.40) | NPC1RAB9ASMN1; SMN2CTSKDDX3X | |
| Trifluoroacetic Acid SCHEMBL5791905 | 0.86 | RAB9A (0.42) | NPC1RAB9ASMN1; SMN2TP53MEN1 | |
| Trifluoroacetic Acid SCHEMBL5794373 | 0.85 | MAPT (0.45) | NPC1RAB9ASMN1; SMN2TP53MEN1 | |
| Trifluoroacetic Acid SCHEMBL5791713 | 0.85 | CTSK (0.37) | CTSKFGFR4CTSLCTSBCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006027211-A1 | 2,4-SUBSTITUTED PYRIMIDINES AS CYSTEINE PROTEASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2006-03-16 | — | — | WO | claimed |
| WO-2006027211-A1 | 2,4-SUBSTITUTED PYRIMIDINES AS CYSTEINE PROTEASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2006-03-16 | — | — | WO | disclosed |