Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 1/20 | 0.60 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.53 |
| ▸ | MPO | P05164 | 2/20 | 0.49 |
| ▸ | MMP12 | P39900 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.48 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.48 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.48 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4031727 | 0.83 | AKR1B1 (0.67) | AKR1B1TDP1L3MBTL1MPOHDAC8 | |
| SCHEMBL452362 | 0.81 | TDP1 (0.79) | AKR1B1KEAP1TDP1L3MBTL1FFAR1 | |
| SCHEMBL1737314 | 0.80 | AKR1B1 (0.74) | AKR1B1KEAP1TDP1L3MBTL1MPO | |
| SCHEMBL30451705 | 0.80 | AKR1B1 (0.74) | AKR1B1KEAP1TDP1L3MBTL1MPO | |
| SCHEMBL31596300 | 0.79 | TDP1 (0.76) | AKR1B1KEAP1TDP1L3MBTL1FFAR1 | |
| SCHEMBL497371 | 0.78 | KEAP1 (0.73) | KEAP1TDP1L3MBTL1FFAR1MMP12 | |
| SCHEMBL29191322 | 0.78 | AKR1B1 (0.59) | AKR1B1SMN1; SMN2GAA | |
| SCHEMBL8100591 | 0.77 | AKR1B1 (0.69) | AKR1B1MPOMMP12 | |
| SCHEMBL11751573 | 0.77 | IAPP (0.59) | AKR1B1MPO | |
| SCHEMBL154267 | 0.76 | TDP1 (0.72) | KEAP1TDP1L3MBTL1FFAR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006042007-A2 | CHROMENONE COMPOUNDS AS CALCILYTICS | NPS PHARMACEUTICALS, INC. (US) | 2006-04-20 | — | — | WO | disclosed |
| CN-1213013-C | Process for synthesizing 1-ortho-hydroxyphenyl butanone | LAIYANG AGRICULTURAL COLLEGE (CN) | 2005-08-03 | — | — | CN | disclosed |
| CN-1102567-C | Application of compound 1-o-hydroxyphenyl butanone | LAIYANG AGRICULTURAL COLLEGE (CN) | 2003-03-05 | — | — | CN | disclosed |