SCHEMBL452362

SCHEMBL452362

O=C(CCc1ccccc1)Cc1ccccc1

nearest known ligand 0.79

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 2/20 0.79
L3MBTL1 Q9Y468 1/20 0.79
KEAP1 Q14145 1/20 0.64
ALDH1A1 P00352 2/20 0.60
FFAR1 O14842 1/20 0.59
TRPA1 O75762 1/20 0.56
CES2 O00748 1/20 0.56
CES1 P23141 1/20 0.56
AKR1B1 P15121 1/20 0.56
HDAC2 Q92769 2/20 0.55
HDAC8 Q9BY41 2/20 0.55
HDAC6 Q9UBN7 2/20 0.55
HDAC1 Q13547 2/20 0.54
HDAC3 O15379 1/20 0.54
MAPK1 P28482 1/20 0.54
ADRA1A P35348 1/20 0.54
HDAC4 P56524 1/20 0.54
SLC6A3 Q01959 1/20 0.54
SMN1; SMN2 Q16637 1/20 0.54
HDAC7 Q8WUI4 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31596300 0.98 TDP1 (0.76) TDP1L3MBTL1KEAP1ALDH1A1FFAR1
SCHEMBL154267 0.90 TDP1 (0.72) TDP1L3MBTL1KEAP1ALDH1A1FFAR1
SCHEMBL11223785 0.89 L3MBTL1 (0.70) TDP1L3MBTL1KEAP1ALDH1A1FFAR1
SCHEMBL15316696 0.89 L3MBTL1 (1.00) TDP1L3MBTL1KEAP1ALDH1A1FFAR1
SCHEMBL8619264 0.88 CES1 (0.64) TDP1L3MBTL1KEAP1ALDH1A1FFAR1
SCHEMBL497371 0.88 KEAP1 (0.73) TDP1L3MBTL1KEAP1ALDH1A1FFAR1
SCHEMBL8664876 0.87 HDAC1 (0.67) TDP1L3MBTL1KEAP1ALDH1A1CES2
SCHEMBL6512327 0.86 CES1 (0.61) TDP1L3MBTL1KEAP1ALDH1A1FFAR1
SCHEMBL107423 0.86 KEAP1 (0.70) TDP1L3MBTL1KEAP1ALDH1A1FFAR1
SCHEMBL712597 0.86 KEAP1 (0.70) TDP1L3MBTL1KEAP1ALDH1A1FFAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 106 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2463374-A2 Isolated alcohol dehydrogenase enzymes and uses thereof Bio Architecture Lab, Inc. (US) 2012-06-13 EP claimed
US-20090155873-A1 BIOFUEL PRODUCTION BIO ARCHITECTURE LAB, INC. (US) 2009-06-18 US claimed
US-20090139134-A1 BIOFUEL PRODUCTION BIO ARCHITECTURE LAB, INC. (US) 2009-06-04 US claimed
EP-3230463-B2 RAPID PRETREATMENT APALTA PATENTS OUE (EE) 2025-07-16 EP disclosed
CN-113905890-B Method for transferring an embossed structure to a coating composition by pretreatment of an embossing tool for transfer 巴斯夫涂料有限公司 2024-12-27 CN disclosed
US-20240425893-A1 RAPID PRETREATMENT Apalta Patents OÜ (EE) 2024-12-26 US disclosed
US-12054761-B2 Rapid pretreatment Apalta Patents OÜ (EE) 2024-08-06 US disclosed
CN-112969733-B Aqueous base formulations based on functionalized polyurethanes 巴斯夫欧洲公司 2024-02-20 CN disclosed
US-11821047-B2 High pressure zone formation for pretreatment Apalta Patent OÜ (EE) 2023-11-21 US disclosed
US-20230348396-A1 HYDROXYBENZAMIDE DERIVATIVES AND METHODS OF USE IN TREATING DIABETES THE BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA (US) 2023-11-02 US disclosed
US-20230295678-A1 RAPID PRETREATMENT Apalta Patents OÜ (EE) 2023-09-21 US disclosed
US-4983739-A Optically active styrene compounds CIBA-GEIGY CORPORATION (US) 1991-01-08 US disclosed
US-4954592-A Optically active styrene derivatives, polymers obtained from these, complexes with iridium(I) and their use CIBA-GEIGY CORPORATION (US) 1990-09-04 US disclosed
US-4904790-A Optically active styrene compounds substituted by a pyridinyl group CIBA-GEIGY CORPORATION (US) 1990-02-27 US disclosed
US-4891412-A Optically active styrene derivatives, polymers obtained from these, complexes with iridium(I) and their use CIBA-GEIGY CORPORATION (US) 1990-01-02 US disclosed
US-4800224-A Optically active styrene derivatives, polymers obtained from these, complexes with iridium(I) and their use CIBA-GEIGY CORPORATION (US) 1989-01-24 US disclosed
EP-0251994-A1 Optically active styrene derivatives, polymers therefrom, complexes with iridium (I) and their use CIBA-GEIGY AG (CH) 1988-01-07 EP disclosed
EP-0239109-A2 Phosphonate angiotensin converting enzyme inhibitors E.R. Squibb & Sons, Inc. (US) 1987-09-30 EP disclosed
EP-0080721-A2 Diphenylalkanoamine derivatives, and their production and use SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1983-06-08 EP disclosed
US-4347248-A DIURETICS AMERICAN CYANAMID COMPANY (US) 1982-08-31 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090139134-A1 BIOFUEL PRODUCTION MGAM, DCXR, MANBA TDP1 2746/4885L3MBTL1 4522/4885KEAP1 1425/4885
US-20230348396-A1 HYDROXYBENZAMIDE DERIVATIVES AND METHODS OF USE IN TREATING DIABETES HSPA5, IAPP, TFEB TDP1 1865/4885L3MBTL1 644/4885KEAP1 269/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.