Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 3/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | PKM | P14618 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | METAP2 | P50579 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5792610 | 0.79 | PTGDR2 (0.36) | ALOX15LMNAPTGDR2 | |
| SCHEMBL6112072 | 0.76 | MEN1 (0.45) | ALDH1A1KMT2AMEN1ALOX15LMNA | |
| SCHEMBL5794378 | 0.76 | ALOX15 (0.37) | ALOX15MAPTLMNAPTGDR2 | |
| SCHEMBL5794763 | 0.74 | PTGDR2 (0.53) | ALDH1A1KMT2AMAPTSMN1; SMN2NPSR1 | |
| SCHEMBL5793255 | 0.71 | DAO (0.42) | ALOX15PKMLMNAPTGDR2 | |
| SCHEMBL5794072 | 0.71 | PDE5A (0.48) | ALDH1A1ALOX15MAPTSMN1; SMN2RAB9A | |
| Acetic Acid SCHEMBL11731347 | 0.65 | SMN1; SMN2 (0.49) | ALDH1A1GAAKMT2AMEN1SLC6A3 | |
| SCHEMBL856450 | 0.63 | GABRA5 (0.61) | ALDH1A1GAAMAPTSMN1; SMN2NPSR1 | |
| SCHEMBL7603041 | 0.63 | — | — | |
| SCHEMBL14814907 | 0.62 | ALDH1A1 (0.80) | ALDH1A1MAPK10KMT2AMEN1ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1644353-A1 | AMIDE-SUBSTITUTED 1,2,4-TRIAZIN-5(2H)-ONES FOR THE TREATMENT OF CHRONICALLY INFLAMMATORY DISEASES | Bayer HealthCare AG (DE) | 2006-04-12 | — | — | EP | disclosed |
| WO-2005003118-A1 | AMIDE-SUBSTITUTED 1,2,4-TRIAZIN-5(2H)-ONES FOR THE TREATMENT OF CHRONICALLY INFLAMMATORY DISEASES | BAYER HEALTHCARE AG (DE) | 2005-01-13 | — | — | WO | disclosed |