Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 10/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | S1PR2 | O95136 | 2/20 | 0.33 |
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.31 |
| ▸ | AGTR2 | P50052 | 2/20 | 0.31 |
| ▸ | GHSR | Q92847 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5794378 | 0.82 | ALOX15 (0.37) | PTGDR2ALOX15S1PR2SLC22A12CYP3A4 | |
| SCHEMBL5791696 | 0.80 | EPHX2 (0.32) | PTGDR2SLC22A12AGTR2LMNA | |
| SCHEMBL5793463 | 0.79 | ALDH1A1 (0.41) | PTGDR2ALOX15LMNA | |
| SCHEMBL5793865 | 0.78 | PLA2G7 (0.48) | CYP3A4CYP2D6PLA2G7 | |
| SCHEMBL6112072 | 0.78 | MEN1 (0.45) | PTGDR2ALOX15CYP3A4CYP2D6PLA2G7 | |
| SCHEMBL5794763 | 0.76 | PTGDR2 (0.53) | PTGDR2LMNA | |
| SCHEMBL5793255 | 0.73 | DAO (0.42) | PTGDR2ALOX15CYP3A4CYP2D6PLA2G7 | |
| SCHEMBL5764503 | 0.71 | GPR84 (0.36) | GHSRLMNA | |
| SCHEMBL5794072 | 0.69 | PDE5A (0.48) | PTGDR2ALOX15CYP3A4CYP2D6LMNA | |
| SCHEMBL6112515 | 0.61 | ALOX15 (0.52) | PTGDR2ALOX15CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1644353-A1 | AMIDE-SUBSTITUTED 1,2,4-TRIAZIN-5(2H)-ONES FOR THE TREATMENT OF CHRONICALLY INFLAMMATORY DISEASES | Bayer HealthCare AG (DE) | 2006-04-12 | — | — | EP | disclosed |
| WO-2005003118-A1 | AMIDE-SUBSTITUTED 1,2,4-TRIAZIN-5(2H)-ONES FOR THE TREATMENT OF CHRONICALLY INFLAMMATORY DISEASES | BAYER HEALTHCARE AG (DE) | 2005-01-13 | — | — | WO | disclosed |