Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR4 | P22455 | 1/20 | 0.41 |
| ▸ | CTSK | P43235 | 11/20 | 0.40 |
| ▸ | GPR4 | P46093 | 1/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.33 |
| ▸ | CTSB | P07858 | 3/20 | 0.33 |
| ▸ | CTSS | P25774 | 3/20 | 0.33 |
| ▸ | CTSL | P07711 | 2/20 | 0.33 |
| ▸ | CTSC | P53634 | 2/20 | 0.33 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.31 |
| ▸ | IDO1 | P14902 | 1/20 | 0.31 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.31 |
| ▸ | XDH | P47989 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3320226 | 0.88 | CTSK (0.47) | FGFR4CTSKGPR4GPR119CTSB | |
| SCHEMBL5791035 | 0.80 | CTSK (0.45) | FGFR4CTSKGPR4GPR119XDH | |
| SCHEMBL8270004 | 0.80 | CTSK (0.40) | FGFR4CTSKGPR4GPR119AAK1 | |
| SCHEMBL5792575 | 0.77 | CTSK (0.44) | FGFR4CTSKGPR4CTSBCTSS | |
| SCHEMBL5791380 | 0.76 | CTSK (0.33) | FGFR4CTSKCTSS | |
| SCHEMBL8268828 | 0.75 | CTSK (0.42) | FGFR4CTSKGPR4GPR119CTSB | |
| SCHEMBL5791716 | 0.75 | FGFR4 (0.35) | FGFR4CTSKCTSSCTSL | |
| SCHEMBL8270028 | 0.75 | GPR119 (0.37) | FGFR4CTSKGPR4GPR119CTSB | |
| SCHEMBL5794364 | 0.75 | GPR119 (0.37) | FGFR4CTSKGPR4GPR119CTSB | |
| SCHEMBL5791034 | 0.74 | CTSK (0.42) | FGFR4CTSKGPR4CTSBCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006027211-A1 | 2,4-SUBSTITUTED PYRIMIDINES AS CYSTEINE PROTEASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2006-03-16 | — | — | WO | claimed |
| WO-2006027211-A1 | 2,4-SUBSTITUTED PYRIMIDINES AS CYSTEINE PROTEASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2006-03-16 | — | — | WO | disclosed |