Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | DRD4 | P21917 | 1/20 | 0.33 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | BCHE | P06276 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL606843 | 0.86 | ALDH1A1 (0.57) | KDM4EALDH1A1LMNASMN1; SMN2CYP1A2 | |
| SCHEMBL612454 | 0.86 | DRD4 (0.36) | ADORA2ADRD4TMEM97SIGMAR1 | |
| SCHEMBL603627 | 0.73 | SIGMAR1 (0.43) | DRD4TMEM97SIGMAR1 | |
| SCHEMBL606684 | 0.72 | ACHE (0.54) | KDM4EALDH1A1LMNASIGMAR1MEN1 | |
| SCHEMBL604819 | 0.71 | MEN1 (0.43) | KDM4EALDH1A1LMNADRD4TMEM97 | |
| SCHEMBL5480509 | 0.71 | CHRNA7 (0.49) | KDM4ESMN1; SMN2DRD4SIGMAR1 | |
| SCHEMBL606943 | 0.69 | SIGMAR1 (0.45) | DRD4TMEM97SIGMAR1 | |
| SCHEMBL5477748 | 0.69 | L3MBTL1 (0.53) | KDM4EALDH1A1LMNASMN1; SMN2ADORA2A | |
| SCHEMBL606660 | 0.69 | JAK2 (0.42) | ALDH1A1DRD4TMEM97SIGMAR1 | |
| SCHEMBL606818 | 0.68 | OPRM1 (0.45) | LMNACYP2D6DRD4TMEM97SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1651634-A1 | IMIDAZOL DERIVATIVES OF PIPERIDINE AS HISTAMINE ANTAGONISTS | AstraZeneca AB (SE) | 2006-05-03 | — | — | EP | disclosed |
| WO-2005014579-A1 | IMIDAZOL DERIVATIVES OF PIPERDINE AS HISTAMINE ANTAGONISTS | ASTRAZENECA AB (SE) | 2005-02-17 | — | — | WO | disclosed |