Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.55 |
| ▸ | RAB9A | P51151 | 6/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.55 |
| ▸ | MEN1 | O00255 | 4/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | GLA | P06280 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 2/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | CASP3 | P42574 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5796079 | 1.00 | NPC1 (0.55) | NPC1RAB9AALDH1A1KDM4EMEN1 | |
| SCHEMBL27178158 | 0.92 | RAB9A (0.60) | NPC1RAB9AALDH1A1KDM4EMEN1 | |
| SCHEMBL27178150 | 0.92 | RAB9A (0.60) | NPC1RAB9AALDH1A1KDM4EMEN1 | |
| SCHEMBL18988652 | 0.78 | RAB9A (0.46) | NPC1RAB9AALDH1A1KDM4EMEN1 | |
| SCHEMBL18988651 | 0.78 | RAB9A (0.46) | NPC1RAB9AALDH1A1KDM4EMEN1 | |
| SCHEMBL27178007 | 0.77 | ALDH1A1 (0.54) | NPC1RAB9AALDH1A1KDM4EMEN1 | |
| SCHEMBL27178193 | 0.77 | ALDH1A1 (0.54) | NPC1RAB9AALDH1A1KDM4EMEN1 | |
| SCHEMBL27178015 | 0.77 | ALDH1A1 (0.54) | NPC1RAB9AALDH1A1KDM4EMEN1 | |
| SCHEMBL4266412 | 0.76 | KCNK3 (0.61) | NPC1RAB9AALDH1A1KDM4EMEN1 | |
| SCHEMBL1562144 | 0.75 | NPC1 (0.72) | NPC1RAB9AALDH1A1KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0912467-B1 | ASYMMETRIC HYDROGENATION METHOD OF A KETONIC COMPOUND AND DERIVATIVE | RHODIA CHIMIE SA (FR) | 2002-04-24 | — | — | EP | claimed |
| EP-0912467-A1 | ASYMMETRIC HYDROGENATION METHOD OF A KETONIC COMPOUND AND DERIVATIVE | RHODIA CHIMIE (FR) | 1999-05-06 | — | — | EP | claimed |
| WO-1998000375-A1 | ASYMMETRIC HYDROGENATION METHOD OF A KETONIC COMPOUND AND DERIVATIVE | RHODIA CHIMIE (FR) | 1998-01-08 | — | — | WO | claimed |
| WO-2006048546-A1 | USE OF AN AROMATIC CARBOXYLIC ACID IN AN ASYMMETRIC CATALYSIS REACTION | SHASUN PHARMA SOLUTIONS LIMITED (GB) | 2006-05-11 | — | — | WO | disclosed |
| WO-2005080299-A1 | NOVEL MONOSULFONYLATED AND CARBONYLATED CHIRAL COMPOUNDS DERIVED FROM A DIAMINE OR AN AMINOALCOHOL AND CARRYING A PYRROLIDINYL GROUP, THE PREPARATION THEREOF, AND THE APPLICATIONS OF THE SAME IN ASYMMETRICAL CATALYSIS | RHODIA CHIMIE (FR) | 2005-09-01 | — | — | WO | disclosed |
| US-20040102649-A1 | Water soluble chiral diphoshpines | RHODIA CHIMIE (FR) | 2004-05-27 | — | — | US | disclosed |
| US-20030225297-A1 | Process for preparing chiral diphosphines | RHODIA CHIMIE | 2003-12-04 | — | — | US | disclosed |
| US-6646106-B1 | Polymerizing chiral diphosphine having a C2 axis of symmetry, with one or several polymerizable monomers, said chiral diphosphine consisting of a chiral body bearing two identical functional groups | RHODIA CHIMIE (FR) | 2003-11-11 | — | — | US | disclosed |
| US-6610875-B1 | Forming bidentate ligands ofr assymetric catalysts; bromina-ting diaryldiol; esterifying with sulfonic acid; substituting cyano for bromine groups; coupling with a dicyclophosphine | RHODIA CHIMIE (FR) | 2003-08-26 | — | — | US | disclosed |
| EP-1268496-A1 | WATER SOLUBLE CHIRAL DIPHOSPHINES | RHODIA CHIMIE (FR) | 2003-01-02 | — | — | EP | disclosed |
| EP-1161481-B1 | OPTICALLY ACTIVE LINEAR POLYMER USED AS LIGAND IN THE PREPARATION OF METALLIC COMPLEXES DESIGNED FOR ASYMMETRIC CATALYSIS | RHODIA CHIMIE SA (FR) | 2002-12-04 | — | — | EP | disclosed |
| EP-0912467-B1 | ASYMMETRIC HYDROGENATION METHOD OF A KETONIC COMPOUND AND DERIVATIVE | RHODIA CHIMIE SA (FR) | 2002-04-24 | — | — | EP | disclosed |
| EP-1161481-A1 | OPTICALLY ACTIVE LINEAR POLYMER USED AS LIGAND IN THE PREPARATION OF METALLIC COMPLEXES DESIGNED FOR ASYMMETRIC CATALYSIS | RHODIA CHIMIE (FR) | 2001-12-12 | — | — | EP | disclosed |
| EP-1153031-A1 | METHOD FOR PREPARING CHIRAL DIPHOSPHINES | RHODIA CHIMIE (FR) | 2001-11-14 | — | — | EP | disclosed |
| WO-2001074828-A1 | WATER SOLUBLE CHIRAL DIPHOSPHINES | RHODIA CHIMIE (FR) | 2001-10-11 | — | — | WO | disclosed |
| US-6166257-A | METAL COMPLEX OF AN OPTICALLY ACTIVE BIS(1-PHOSPHA-2,3-DIPHENYL-4,5-DIMETHYLNORBORNADIENE) | RHODIA CHIMIE (FR) | 2000-12-26 | — | — | US | disclosed |
| WO-2000052081-A1 | OPTICALLY ACTIVE LINEAR POLYMER USED AS LIGAND IN THE PREPARATION OF METALLIC COMPLEXES DESIGNED FOR ASYMMETRIC CATALYSIS | RHODIA CHIMIE (FR) | 2000-09-08 | — | — | WO | disclosed |
| WO-2000049028-A1 | METHOD FOR PREPARING CHIRAL DIPHOSPHINES | RHODIA CHIMIE (FR) | 2000-08-24 | — | — | WO | disclosed |
| EP-0912467-A1 | ASYMMETRIC HYDROGENATION METHOD OF A KETONIC COMPOUND AND DERIVATIVE | RHODIA CHIMIE (FR) | 1999-05-06 | — | — | EP | disclosed |
| WO-1998000375-A1 | ASYMMETRIC HYDROGENATION METHOD OF A KETONIC COMPOUND AND DERIVATIVE | RHODIA CHIMIE (FR) | 1998-01-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040102649-A1 | Water soluble chiral diphoshpines | ADRA1B, ADRB1, ADRA1A | NPC1 1258/4885RAB9A 3476/4885ALDH1A1 1325/4885 |
| US-20030225297-A1 | Process for preparing chiral diphosphines | CYP1A1, NR5A1, AR | NPC1 553/4885RAB9A 1432/4885ALDH1A1 964/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.