Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTTP | P55157 | 6/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | L3MBTL3 | Q96JM7 | 4/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.46 |
| ▸ | TP53BP1 | Q12888 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.43 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.43 |
| ▸ | FAAH | O00519 | 1/20 | 0.42 |
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.41 |
| ▸ | SMYD2 | Q9NRG4 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | UBE2M | P61081 | 1/20 | 0.39 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13419451 | 0.99 | MTTP (0.47) | MTTPMEN1KMT2AL3MBTL3L3MBTL1 | |
| SCHEMBL13419205 | 0.94 | MTTP (0.54) | MTTPMEN1KMT2AHCRTR1HCRTR2 | |
| SCHEMBL5796728 | 0.94 | MTTP (0.54) | MTTPMEN1KMT2AHCRTR1HCRTR2 | |
| SCHEMBL13419184 | 0.93 | MTTP (0.53) | MTTPMEN1KMT2AHCRTR1HCRTR2 | |
| SCHEMBL13419201 | 0.88 | FAAH (0.48) | MTTPHCRTR1HCRTR2FAAHUBE2M | |
| SCHEMBL13419152 | 0.87 | SCD5 (0.50) | MTTPHCRTR1HCRTR2FAAH | |
| SCHEMBL13419083 | 0.87 | HTR2C (0.48) | MTTPCYP2C9HCRTR1HCRTR2FAAH | |
| SCHEMBL13419477 | 0.87 | MTTP (0.47) | MTTPCYP2C9HCRTR1HCRTR2FAAH | |
| SCHEMBL13419545 | 0.87 | MTTP (0.51) | MTTPHCRTR1HCRTR2FAAHTSHR | |
| SCHEMBL13419471 | 0.87 | MTTP (0.47) | MTTPCYP2C9HCRTR1HCRTR2FAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7674803-B2 | Thiazolypiperidine derivatives as MTP inhibitors | MERCK PATENT GMBH (DE) | 2010-03-09 | — | — | US | disclosed |
| US-7674803-B2 | Thiazolypiperidine derivatives as MTP inhibitors | MERCK PATENT GMBH (DE) | 2010-03-09 | — | — | US | disclosed |