Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | VEGFA | P15692 | 1/20 | 0.40 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5481632 | 0.76 | P2RX4 (0.52) | SMN1; SMN2MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL5800712 | 0.75 | HPGD (0.49) | HTTSMN1; SMN2CYP2D6KDM4ETP53 | |
| SCHEMBL9118024 | 0.73 | CYP3A4 (0.51) | HTTSMN1; SMN2CYP2D6KDM4ETP53 | |
| SCHEMBL4494422 | 0.73 | MAPK14 (0.46) | HTTSMN1; SMN2CYP2D6KDM4ETP53 | |
| SCHEMBL9453625 | 0.73 | KMT2A (0.54) | SMN1; SMN2KDM4EMEN1KMT2AALDH1A1 | |
| SCHEMBL7521742 | 0.70 | HTT (0.45) | HTTSMN1; SMN2CYP2D6KDM4ETP53 | |
| SCHEMBL3993878 | 0.70 | MAPK14 (0.45) | HTTSMN1; SMN2CYP2D6KDM4ETP53 | |
| SCHEMBL399970 | 0.69 | MAPK14 (0.52) | HTTSMN1; SMN2CYP2D6KDM4ETP53 | |
| SCHEMBL5800407 | 0.68 | KMT2A (0.44) | HTTSMN1; SMN2KDM4EMEN1KMT2A | |
| SCHEMBL3195504 | 0.68 | HSPD1 (0.50) | HTTSMN1; SMN2MAPK14HSP90AA1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006070292-A2 | PYRIMIDINE COMPOUNDS AS ANTI-ICTOGENIC AND/OR ANTI-EPILEPTOGENIC AGENTS | QUEEN'S UNIVERSITY AT KINGSTON (US) | 2006-07-06 | — | — | WO | disclosed |