Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 8/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.40 |
| ▸ | OPRL1 | P41146 | 4/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.40 |
| ▸ | BDKRB2 | P30411 | 1/20 | 0.39 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.39 |
| ▸ | NPC1L1 | Q9UHC9 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5802411 | 0.95 | ENPP2 (0.46) | ENPP2OPRM1OPRK1OPRL1OPRD1 | |
| SCHEMBL5799004 | 0.88 | ENPP2 (0.50) | ENPP2OPRM1OPRK1OPRL1OPRD1 | |
| SCHEMBL5784109 | 0.87 | ENPP2 (0.41) | ENPP2OPRM1OPRK1OPRL1OPRD1 | |
| SCHEMBL5799989 | 0.86 | ENPP2 (0.44) | ENPP2OPRM1OPRK1OPRL1OPRD1 | |
| SCHEMBL6475328 | 0.84 | ENPP2 (0.40) | ENPP2OPRM1OPRK1OPRL1OPRD1 | |
| SCHEMBL5800911 | 0.81 | NPC1L1 (0.49) | OPRM1OPRK1OPRL1OPRD1NPC1L1 | |
| SCHEMBL5783193 | 0.81 | L3MBTL1 (0.44) | ENPP2OPRM1OPRK1OPRL1OPRD1 | |
| SCHEMBL5803270 | 0.81 | OPRM1 (0.46) | ENPP2OPRM1OPRK1OPRL1OPRD1 | |
| SCHEMBL5801972 | 0.80 | OPRM1 (0.51) | OPRM1OPRK1OPRL1OPRD1 | |
| SCHEMBL5802331 | 0.80 | BDKRB2 (0.47) | ENPP2OPRM1OPRK1OPRL1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1329451-B1 | SPIRO COMPOUNDS AND ADHESION MOLECULE INHIBITORS CONTAINING THE SAME AS THE ACTIVE INGREDIENT | TORAY INDUSTRIES (JP) | 2006-08-23 | — | — | EP | disclosed |
| EP-1329451-A1 | SPIRO COMPOUNDS AND ADHESION MOLECULE INHIBITORS CONTAINING THE SAME AS THE ACTIVE INGREDIENT | TORAY INDUSTRIES, INC. (JP) | 2003-07-23 | — | — | EP | disclosed |