SCHEMBL5800514

SCHEMBL5800514

N#Cc1ccc2c(c1)N=CCS2

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TRPA1 O75762 1/20 0.35
IMPDH2 P12268 1/20 0.33
IMPDH1 P20839 1/20 0.33
CYP19A1 P11511 2/20 0.32
HDAC4 P56524 2/20 0.31
HDAC7 Q8WUI4 2/20 0.31
HDAC8 Q9BY41 2/20 0.31
HDAC6 Q9UBN7 2/20 0.31
HDAC5 Q9UQL6 2/20 0.31
HDAC1 Q13547 1/20 0.31
NOS3 P29474 1/20 0.31
NOS1 P29475 1/20 0.31
NOS2 P35228 1/20 0.31
DRD2 P14416 2/20 0.31
DRD3 P35462 2/20 0.31
PNMT P11086 1/20 0.31
NPC1 O15118 1/20 0.31
RAB9A P51151 1/20 0.31
KDM1A O60341 1/20 0.30
HDAC3 O15379 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7038650 0.69 TRPA1 (0.44) TRPA1IMPDH2IMPDH1CYP19A1NOS3
SCHEMBL8276 0.67 TRPA1 (0.41) TRPA1
SCHEMBL28414758 0.66 SNCA (0.37) IMPDH2IMPDH1HDAC4HDAC7HDAC8
SCHEMBL11017385 0.66 TRPA1 (0.44) TRPA1CYP19A1NOS3NOS1NOS2
SCHEMBL27711972 0.66 IMPDH2 (0.36) TRPA1IMPDH2IMPDH1CYP19A1DRD2
SCHEMBL14217829 0.64 TRPA1 (0.40) TRPA1NOS3NOS1NOS2DRD2
SCHEMBL28039609 0.63 PNMT (0.42) TRPA1CYP19A1NOS3NOS1NOS2
SCHEMBL9507653 0.62 SNCA (0.47) IMPDH2IMPDH1HDAC4HDAC7HDAC8
SCHEMBL9511458 0.62 SNCA (0.47) IMPDH2IMPDH1HDAC4HDAC7HDAC8
SCHEMBL21341328 0.62 IMPDH2 (0.33) IMPDH2IMPDH1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20190276744-A1 LIQUID CRYSTAL COMPOSITION SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2019-09-12 US disclosed
WO-2006088798-A2 MODULATION OF HYPOTHALAMIC ATP-SENSITIVE POTASSIUM CHANNELS ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY (US) 2006-08-24 WO disclosed