Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.45 |
| ▸ | MEN1 | O00255 | 4/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | PKM | P14618 | 2/20 | 0.44 |
| ▸ | HSPB1 | P04792 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1472050 | 0.87 | CCR2 (0.48) | LMNAALDH1A1POLBPLA2G7HPGD | |
| SCHEMBL5798868 | 0.83 | PLA2G7 (0.49) | LMNAALDH1A1POLBPLA2G7HPGD | |
| SCHEMBL1472167 | 0.82 | CCR2 (0.46) | LMNAALDH1A1POLBPLA2G7HPGD | |
| SCHEMBL8141281 | 0.81 | HSPB1 (0.57) | ALDH1A1POLBPLA2G7KMT2AMEN1 | |
| SCHEMBL31457196 | 0.80 | HSPB1 (0.57) | ALDH1A1POLBPLA2G7KMT2AMEN1 | |
| SCHEMBL11092359 | 0.78 | PDE7A (0.53) | ALDH1A1POLBPLA2G7KMT2AMEN1 | |
| SCHEMBL4780615 | 0.78 | HSPB1 (0.54) | LMNAALDH1A1POLBKMT2AMEN1 | |
| SCHEMBL4540927 | 0.78 | MEN1 (0.55) | LMNAALDH1A1POLBHPGDL3MBTL1 | |
| SCHEMBL1472230 | 0.77 | LMNA (0.63) | LMNAALDH1A1POLBHPGDKMT2A | |
| SCHEMBL5800965 | 0.76 | CRHBP (0.67) | LMNAALDH1A1POLBHPGDL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1651595-A2 | UBIQUITIN LIGASE INHIBITORS | Rigel Pharmaceuticals, Inc. (US) | 2006-05-03 | — | — | EP | claimed |
| WO-2005007621-A2 | UBIQUITIN LIGASE INHIBITORS | RIGEL PHARMACEUTICALS, INC. (US) | 2005-01-27 | — | — | WO | claimed |