Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 6/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | IDE | P14735 | 1/20 | 0.37 |
| ▸ | HRH2 | P25021 | 3/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4859493 | 0.85 | ALDH1A1 (0.50) | RORCALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL4858049 | 0.81 | MEN1 (0.52) | RORCALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL5202233 | 0.74 | HRH2 (0.41) | ALDH1A1KMT2AMEN1MAPTHRH2 | |
| SCHEMBL5203151 | 0.73 | ALDH1A1 (0.50) | ALDH1A1KMT2AMEN1MAPTIDE | |
| SCHEMBL4857600 | 0.68 | HTR2A (0.49) | ALDH1A1MAPTHRH2HTR2AHTR2C | |
| SCHEMBL4849753 | 0.68 | HRH2 (0.52) | HRH2HTR2AHTR2CHTR2B | |
| SCHEMBL5705162 | 0.66 | RORC (0.51) | RORCALDH1A1KMT2AMEN1CYP2C9 | |
| SCHEMBL4858050 | 0.66 | RAB9A (0.62) | RORCALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL4855807 | 0.65 | KDM4E (0.48) | RORCALDH1A1USP2 | |
| SCHEMBL5202270 | 0.65 | MAPT (0.43) | ALDH1A1KMT2AMEN1MAPTUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1654253-A1 | SUBSTITUTED 3-PYRROLIDIN-INDOLE DERIVATIVES | Grünenthal GmbH (DE) | 2006-05-10 | — | — | EP | disclosed |
| WO-2005019208-A1 | SUBSTITUTED 3-PYRROLIDIN-INDOLE DERIVATIVES | Grünenthal GmbH (DE) | 2005-03-03 | — | — | WO | disclosed |