Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 5/20 | 0.42 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.42 |
| ▸ | PSMB11 | A5LHX3 | 1/20 | 0.41 |
| ▸ | PSMA7 | O14818 | 1/20 | 0.41 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.41 |
| ▸ | PSMA1 | P25786 | 1/20 | 0.41 |
| ▸ | PSMA2 | P25787 | 1/20 | 0.41 |
| ▸ | PSMA3 | P25788 | 1/20 | 0.41 |
| ▸ | PSMA4 | P25789 | 1/20 | 0.41 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.41 |
| ▸ | PSMB9 | P28065 | 1/20 | 0.41 |
| ▸ | PSMA5 | P28066 | 1/20 | 0.41 |
| ▸ | PSMB4 | P28070 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4859493 | 0.74 | ALDH1A1 (0.50) | MAPTKMT2AALDH1A1TP53MEN1 | |
| SCHEMBL5203151 | 0.72 | ALDH1A1 (0.50) | MAPTKMT2AALDH1A1MEN1USP2 | |
| SCHEMBL5204533 | 0.71 | ALDH1A1 (0.46) | MAPTKMT2ASMN1; SMN2ALDH1A1TP53 | |
| SCHEMBL4861066 | 0.70 | MEN1 (0.46) | MAPTKMT2AALDH1A1TP53MEN1 | |
| SCHEMBL5240385 | 0.68 | SLC5A1 (0.52) | MAPTSMN1; SMN2ALDH1A1DRD4 | |
| SCHEMBL4857534 | 0.67 | DRD4 (0.40) | MAPTKMT2ASMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL8299569 | 0.66 | DRD4 (0.56) | THRBKMT2ASMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL5206126 | 0.66 | KMT2A (0.42) | KMT2ASMN1; SMN2ALDH1A1MEN1RAB9A | |
| SCHEMBL5202530 | 0.65 | ALDH1A1 (0.42) | MAPTKMT2ASMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL5204500 | 0.65 | TPSAB1 (0.47) | MAPTKMT2ASMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1654253-B1 | SUBSTITUTED 3-PYRROLIDIN-INDOLE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2007-01-03 | — | — | EP | claimed |
| EP-1654253-B1 | SUBSTITUTED 3-PYRROLIDIN-INDOLE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2007-01-03 | — | — | EP | disclosed |