Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH2 | P25021 | 11/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 2/20 | 0.39 |
| ▸ | HTR2C | P28335 | 2/20 | 0.39 |
| ▸ | HTR2B | P41595 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4858049 | 0.81 | MEN1 (0.52) | MAPTNPC1POLBHPGDNFKB1 | |
| SCHEMBL4857600 | 0.78 | HTR2A (0.49) | HRH2MAPTPOLBHTR2AHTR2C | |
| SCHEMBL5206944 | 0.78 | RAB9A (0.55) | MAPTNPC1POLBHPGDRAB9A | |
| SCHEMBL5801705 | 0.74 | RORC (0.47) | HRH2MAPTHTR2AHTR2CHTR2B | |
| SCHEMBL4849753 | 0.73 | HRH2 (0.52) | HRH2HTR2AHTR2CHTR2B | |
| SCHEMBL5205671 | 0.69 | MAPT (0.47) | HRH2MAPTNPC1POLBHPGD | |
| SCHEMBL5203557 | 0.69 | ALDH1A1 (0.50) | HRH2RAB9AKMT2AMEN1ALDH1A1 | |
| SCHEMBL6779805 | 0.68 | HRH2 (0.75) | HRH2HTR2AHTR2CHTR2B | |
| SCHEMBL4859737 | 0.67 | KMT2A (0.46) | MAPTPOLBRAB9AKMT2AMEN1 | |
| SCHEMBL5201910 | 0.62 | NPC1 (0.42) | HRH2MAPTNPC1RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1654253-B1 | SUBSTITUTED 3-PYRROLIDIN-INDOLE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2007-01-03 | — | — | EP | claimed |
| EP-1654253-B1 | SUBSTITUTED 3-PYRROLIDIN-INDOLE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2007-01-03 | — | — | EP | disclosed |