Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK2 | O43353 | 8/20 | 0.50 |
| ▸ | LCK | P06239 | 7/20 | 0.50 |
| ▸ | KDR | P35968 | 7/20 | 0.50 |
| ▸ | TGFBR1 | P36897 | 6/20 | 0.50 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.42 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.42 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.41 |
| ▸ | FEN1 | P39748 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SYK | P43405 | 4/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.36 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5222484 | 0.88 | RIPK2 (0.45) | RIPK2LCKKDRTGFBR1CSNK1D | |
| SCHEMBL5232870 | 0.81 | RIPK2 (0.45) | RIPK2LCKKDRTGFBR1MEN1 | |
| SCHEMBL5225861 | 0.80 | BCAT2 (0.49) | RIPK2LCKKDRTGFBR1ALOX5AP | |
| SCHEMBL5801938 | 0.76 | TGFBR1 (0.50) | RIPK2LCKKDRTGFBR1CSNK1D | |
| SCHEMBL18589865 | 0.76 | FFAR1 (0.45) | RIPK2LCKKDRTGFBR1ALOX5AP | |
| SCHEMBL761133 | 0.76 | ALDH1A1 (0.45) | RIPK2LCKKDRTGFBR1ALOX5AP | |
| SCHEMBL29598464 | 0.74 | HDAC6 (0.46) | RIPK2LCKKDRTGFBR1 | |
| SCHEMBL5802267 | 0.73 | JAK2 (0.49) | RIPK2LCKKDRTGFBR1JAK2 | |
| SCHEMBL13544749 | 0.71 | HSD11B1 (0.54) | MEN1POLBKMT2ATRPV1NTRK1 | |
| SCHEMBL5224565 | 0.71 | RIPK2 (0.49) | RIPK2LCKKDRTGFBR1CSNK1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1622884-A1 | NEW HETEROCYCLIC AMIDES EXHIBITING AN INHIBITORY ACTIVITY AT THE VANILLOID RECEPTOR 1 (VR1). | AstraZeneca AB (SE) | 2006-02-08 | — | — | EP | claimed |
| WO-2004096784-A1 | NEW HETEROCYCLIC AMIDES EXHIBITING AN INHIBITORY ACTIVITY AT THE VANILLOID RECEPTOR 1 (VR1). | ASTRAZENECA AB (SE) | 2004-11-11 | — | — | WO | claimed |
| EP-1622884-A1 | NEW HETEROCYCLIC AMIDES EXHIBITING AN INHIBITORY ACTIVITY AT THE VANILLOID RECEPTOR 1 (VR1). | AstraZeneca AB (SE) | 2006-02-08 | — | — | EP | disclosed |
| WO-2004096784-A1 | NEW HETEROCYCLIC AMIDES EXHIBITING AN INHIBITORY ACTIVITY AT THE VANILLOID RECEPTOR 1 (VR1). | ASTRAZENECA AB (SE) | 2004-11-11 | — | — | WO | disclosed |