Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 0.42 |
| ▸ | TP53 | P04637 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 7/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 4/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.38 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5808924 | 0.71 | LMNA (0.47) | MAPTTP53SMN1; SMN2NPSR1LMNA | |
| SCHEMBL5805401 | 0.71 | NCOA1 (0.51) | MAPTTP53SMN1; SMN2NPSR1LMNA | |
| SCHEMBL5796637 | 0.69 | LMNA (0.59) | MAPTTP53SMN1; SMN2NPSR1LMNA | |
| SCHEMBL5794482 | 0.69 | MAPT (0.56) | MAPTTP53SMN1; SMN2NPSR1LMNA | |
| SCHEMBL21498009 | 0.67 | MAPT (0.72) | MAPTTP53SMN1; SMN2NPSR1LMNA | |
| SCHEMBL2420495 | 0.66 | ALDH1A1 (0.34) | SMN1; SMN2NPSR1ALDH1A1HTTPOLB | |
| SCHEMBL4922701 | 0.64 | NPSR1 (0.38) | MAPTSMN1; SMN2NPSR1LMNAALDH1A1 | |
| SCHEMBL26546756 | 0.64 | KDR (0.76) | MAPTTP53SMN1; SMN2NPSR1LMNA | |
| SCHEMBL5820332 | 0.63 | LMNA (0.54) | MAPTSMN1; SMN2NPSR1LMNAALDH1A1 | |
| SCHEMBL7292316 | 0.62 | MAPT (0.69) | MAPTTP53SMN1; SMN2NPSR1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006015279-A1 | HETEROCYCLIC DIAMINE COMPOUNDS AS LIGANDS OF THE MELANIN CONCENTRATING HORMONE RECEPTOR USEFUL FOR THE TREATMENT OF OBESITY, DIABETES, EATING AND SEXUAL DISORDERS | NEUROGEN CORPORATION (US) | 2006-02-09 | — | — | WO | claimed |