Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | GUSB | P08236 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.31 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.30 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5808471 | 0.87 | LMNA (0.37) | LMNAMAPK1GUSBGAAMAPT | |
| SCHEMBL5806865 | 0.81 | MAPT (0.40) | LMNAMAPK1GAAMAPTSMN1; SMN2 | |
| SCHEMBL5808980 | 0.76 | LMNA (0.43) | LMNAMAPK1GAAMAPTSMN1; SMN2 | |
| SCHEMBL5806294 | 0.74 | PTGER3 (0.40) | LMNAGUSBMAPTSMN1; SMN2NTRK1 | |
| SCHEMBL5804771 | 0.70 | LMNA (0.37) | LMNAMAPK1GAAMAPTSMN1; SMN2 | |
| SCHEMBL5809123 | 0.69 | NTRK1 (0.38) | LMNAGAASMN1; SMN2NTRK1ALDH1A1 | |
| SCHEMBL5820745 | 0.69 | ALDH1A1 (0.44) | LMNAMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL5821042 | 0.68 | MAPK13 (0.43) | LMNAMAPK1GAAMAPTSMN1; SMN2 | |
| SCHEMBL5806862 | 0.68 | MAPT (0.39) | LMNAMAPK1GAAMAPTSMN1; SMN2 | |
| SCHEMBL5804805 | 0.67 | MAPT (0.40) | LMNAMAPK1GAAMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006075955-A1 | PYRAZOLYL ACYLSULFONAMIDE DERIVATIVES AS ENDOTHELIN CONVERTING ENZYME INHIBITORS AND USEFUL IN THE TREATMENT OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE | ASTRAZENECA AB (SE) | 2006-07-20 | — | — | WO | claimed |