Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5820740 | 0.84 | ALDH1A1 (0.43) | ALDH1A1KDM4EHTTMAPTPOLB | |
| SCHEMBL5804799 | 0.80 | CCR4 (0.34) | ALDH1A1KDM4EHTTP2RY1POLB | |
| SCHEMBL5804793 | 0.76 | AKR1C3 (0.40) | ALDH1A1KDM4EHTTPOLB | |
| SCHEMBL5806865 | 0.75 | MAPT (0.40) | ALDH1A1KDM4EHTTMAPTLMNA | |
| SCHEMBL5805214 | 0.74 | PTGS2 (0.43) | MAPTLMNAMEN1KMT2APTGS1 | |
| SCHEMBL5807078 | 0.72 | POLB (0.58) | ALDH1A1POLBLMNASCN9AKMT2A | |
| SCHEMBL5808763 | 0.72 | MEN1 (0.36) | ALDH1A1HTTMAPTPOLBLMNA | |
| SCHEMBL5804488 | 0.69 | FPR1 (0.43) | ALDH1A1KDM4EHTTMAPTLMNA | |
| SCHEMBL5808474 | 0.69 | LMNA (0.34) | ALDH1A1MAPTLMNAMEN1KMT2A | |
| SCHEMBL5805134 | 0.68 | KCNJ6 (0.40) | ALDH1A1MAPTMEN1KMT2ARIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006075955-A1 | PYRAZOLYL ACYLSULFONAMIDE DERIVATIVES AS ENDOTHELIN CONVERTING ENZYME INHIBITORS AND USEFUL IN THE TREATMENT OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE | ASTRAZENECA AB (SE) | 2006-07-20 | — | — | WO | claimed |