Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 5/20 | 0.33 |
| ▸ | CXCR4 | P61073 | 4/20 | 0.32 |
| ▸ | GNRHR | P30968 | 1/20 | 0.31 |
| ▸ | EGLN1 | Q9GZT9 | 5/20 | 0.31 |
| ▸ | FPR1 | P21462 | 1/20 | 0.31 |
| ▸ | FPR2 | P25090 | 1/20 | 0.31 |
| ▸ | HTR6 | P50406 | 1/20 | 0.31 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.30 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.30 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5807940 | 0.91 | EGLN1 (0.33) | ELANECXCR4EGLN1HTR6ADORA2A | |
| SCHEMBL5809651 | 0.86 | ROCK2 (0.35) | EGLN1ADORA2AADORA1 | |
| SCHEMBL5811632 | 0.85 | EGLN1 (0.33) | CXCR4EGLN1FPR1FPR2HTR6 | |
| SCHEMBL5806875 | 0.83 | EGLN1 (0.35) | ELANECXCR4EGLN1FPR1FPR2 | |
| SCHEMBL5820989 | 0.82 | CYP1A2 (0.40) | — | |
| SCHEMBL5807042 | 0.82 | EGLN1 (0.33) | EGLN1FPR1FPR2 | |
| SCHEMBL5806941 | 0.82 | POLB (0.39) | CXCR4EGLN1 | |
| SCHEMBL5806927 | 0.80 | ROCK2 (0.34) | CXCR4EGLN1FPR1FPR2HTR6 | |
| SCHEMBL5819231 | 0.80 | ADAM17 (0.36) | — | |
| SCHEMBL5808116 | 0.79 | FPR2 (0.38) | CXCR4EGLN1FPR1FPR2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006106416-A1 | PYRIDIL-LACTAMS AND THEIR USE 5 -HTl RECEPTORS LIGAN | PFIZER PRODUCTS INC. (US) | 2006-10-12 | — | — | WO | claimed |
| WO-2006106416-A1 | PYRIDIL-LACTAMS AND THEIR USE 5 -HTl RECEPTORS LIGAN | PFIZER PRODUCTS INC. (US) | 2006-10-12 | — | — | WO | disclosed |