Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | MAP2K3 | P46734 | 1/20 | 0.40 |
| ▸ | MAP2K6 | P52564 | 1/20 | 0.40 |
| ▸ | BTK | Q06187 | 1/20 | 0.40 |
| ▸ | MAP3K19 | Q56UN5 | 1/20 | 0.40 |
| ▸ | NEK10 | Q6ZWH5 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.37 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.35 |
| ▸ | ALPL | P05186 | 1/20 | 0.35 |
| ▸ | KMO | O15229 | 2/20 | 0.34 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.34 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.34 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.34 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.34 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.34 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5807279 | 0.88 | LCK (0.50) | LCKMAP2K3MAP2K6BTKMAP3K19 | |
| SCHEMBL20843885 | 0.69 | LCK (0.49) | LCKMAP2K3MAP2K6BTKMAP3K19 | |
| SCHEMBL9496321 | 0.68 | LCK (0.77) | LCKMAP2K3MAP2K6BTKMAP3K19 | |
| SCHEMBL20839022 | 0.67 | BTK (0.50) | LCKMAP2K3MAP2K6BTKMAP3K19 | |
| SCHEMBL27728270 | 0.66 | EGFR (0.46) | ALPLKMOLMNAEGLN1HAVCR2 | |
| SCHEMBL2909586 | 0.65 | IGFBP5 (0.46) | ALPLKMOEGLN1GRM2 | |
| SCHEMBL31450095 | 0.64 | GABRG2 (0.43) | LCKMAP2K3MAP2K6BTKMAP3K19 | |
| SCHEMBL9592356 | 0.64 | EGFR (0.45) | ALPLEGLN1HAVCR2 | |
| SCHEMBL406782 | 0.63 | KEAP1 (0.50) | TDP1 | |
| SCHEMBL1096218 | 0.63 | KEAP1 (0.50) | ALPLTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060264439-A1 | Inhibitors of polo-like kinase-1 | SUPERGEN, INC. (US) | 2006-11-23 | — | — | US | disclosed |
| WO-2006124996-A2 | INHIBITORS OF POLO-LIKE KINASE-1 | SUPERGEN, INC. (US) | 2006-11-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060264439-A1 | Inhibitors of polo-like kinase-1 | PLK2, PHKG1, PRKDC | LCK 425/4885MAP2K3 391/4885MAP2K6 351/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.