Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | PDE3A | Q14432 | 6/20 | 0.46 |
| ▸ | PDE5A | O76074 | 1/20 | 0.46 |
| ▸ | PDE3B | Q13370 | 5/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | KCNQ3 | O43525 | 2/20 | 0.38 |
| ▸ | KCNQ2 | O43526 | 2/20 | 0.38 |
| ▸ | IGF1R | P08069 | 2/20 | 0.37 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5810385 | 0.81 | PDE3A (0.65) | CYP1A2PDE3APDE5AIGF1RMAPK3 | |
| SCHEMBL17736144 | 0.78 | PTGS2 (0.58) | PDE3APDE3BPTGS2KCNQ3KCNQ2 | |
| SCHEMBL7369957 | 0.77 | PDE3A (0.48) | CYP1A2PDE3APDE5APDE3BIGF1R | |
| SCHEMBL6824334 | 0.74 | PDE3A (0.46) | CYP1A2PDE3APDE5APDE3BPTGS2 | |
| SCHEMBL8888651 | 0.73 | CYP1A2 (0.55) | CYP1A2PDE3APDE5AMAPK1HPGD | |
| SCHEMBL5946755 | 0.72 | PTGS2 (0.42) | PDE3APDE3BPTGS2KCNQ3KCNQ2 | |
| SCHEMBL5946616 | 0.72 | HPGDS (0.43) | PDE3APDE3BPTGS2KCNQ3KCNQ2 | |
| SCHEMBL6818685 | 0.71 | PDE3A (0.47) | CYP1A2PDE3APDE5AIGF1RMAPK3 | |
| SCHEMBL6539289 | 0.71 | CYP1A2 (0.60) | CYP1A2PDE3APDE3BPTGS2HPGD | |
| SCHEMBL8836696 | 0.70 | PTGS2 (0.62) | PTGS2KCNQ3KCNQ2MAPK14JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006038734-A1 | PYRIDAZINONE DERIVATIVES CYTOKINES INHIBITORS | ASTELLAS PHARMA INC. (JP) | 2006-04-13 | — | — | WO | disclosed |