Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3A | Q14432 | 5/20 | 0.46 |
| ▸ | PDE5A | O76074 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.43 |
| ▸ | PDE4A | P27815 | 3/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 5/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.38 |
| ▸ | BLM | P54132 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6824757 | 0.78 | ADORA1 (0.38) | PDE4BPDE4APDE4CPDE4DPTGS1 | |
| SCHEMBL5810385 | 0.77 | PDE3A (0.65) | PDE3APDE5ACYP1A2PDE4BHPGD | |
| SCHEMBL6818685 | 0.77 | PDE3A (0.47) | PDE3APDE5ACYP1A2PDE4BPDE4A | |
| SCHEMBL8186528 | 0.76 | PDE3A (0.60) | PDE3APDE5ACYP1A2PDE4BPDE4A | |
| SCHEMBL8199836 | 0.76 | PDE3A (0.60) | PDE3APDE5ACYP1A2PDE4BPDE4A | |
| SCHEMBL6821442 | 0.74 | HTR6 (0.37) | LMNAPTGS2HPGDMAPK1TP53 | |
| SCHEMBL5810901 | 0.74 | CYP1A2 (0.49) | PDE3APDE5ACYP1A2LMNAPTGS2 | |
| SCHEMBL8193845 | 0.73 | PDE3A (0.56) | PDE3APDE5ACYP1A2PDE4BPDE4A | |
| SCHEMBL8888651 | 0.72 | CYP1A2 (0.55) | PDE3APDE5ACYP1A2LMNAHPGD | |
| SCHEMBL6822604 | 0.72 | PDE4B (0.51) | PDE3APDE5ACYP1A2PDE4BPDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040110763-A1 | Pyrazolopyridine compound and pharmaceutical use thereof | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2004-06-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040110763-A1 | Pyrazolopyridine compound and pharmaceutical use thereof | ADRB1, ADRA1D, ADRB3 | PDE3A 137/4885PDE5A 187/4885CYP1A2 373/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.