Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | NOS3 | P29474 | 1/20 | 0.46 |
| ▸ | NOS1 | P29475 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.43 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.43 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5807811 | 0.85 | HSD11B1 (0.48) | LMNATSHRNOS3NOS1MAPT | |
| SCHEMBL5811080 | 0.84 | TSHR (0.48) | LMNATSHRMAPTHSD11B1HSD17B1 | |
| SCHEMBL3923745 | 0.83 | MAPT (0.49) | TSHRMAPTGAAKMT2AKDM4E | |
| SCHEMBL5806959 | 0.79 | RAB9A (0.54) | TSHRMAPTKMT2APOLBL3MBTL1 | |
| SCHEMBL13621171 | 0.77 | KDM4E (0.59) | LMNATSHRMAPTKMT2APOLB | |
| SCHEMBL14159379 | 0.74 | GABRA5 (0.54) | LMNATSHRMAPTHSD11B1HSD17B1 | |
| SCHEMBL30323744 | 0.74 | CXCR4 (0.49) | LMNANOS3NOS1HRH4KDM4E | |
| SCHEMBL520138 | 0.74 | CXCR4 (0.49) | LMNANOS3NOS1HRH4KDM4E | |
| SCHEMBL4287896 | 0.72 | POLB (0.55) | LMNATSHRMAPTHSD11B1GAA | |
| SCHEMBL18706533 | 0.72 | ALDH1A1 (0.64) | LMNATSHRMAPTGAAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006050908-A1 | INHIBITORS OF 11ΒΕΤΑ-HYDROXY STEROID DEHYDROGENASE TYPE 1 (11BETA-HSD1) | EVOTEC AG (DE) | 2006-05-18 | — | — | WO | disclosed |