Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 5/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | XBP1 | P17861 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | CSF1R | P07333 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.42 |
| ▸ | SIRT1 | Q96EB6 | 3/20 | 0.41 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.41 |
| ▸ | TUBB | P07437 | 1/20 | 0.41 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.41 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.41 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.41 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.41 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5775281 | 0.88 | KDM4E (0.48) | ALOX15ALDH1A1HPGDLMNAMAPT | |
| SCHEMBL9240047 | 0.85 | ALDH1A1 (0.50) | ALOX15ALDH1A1HPGDCYP1A2XBP1 | |
| SCHEMBL9573776 | 0.84 | ALDH1A1 (0.49) | ALOX15ALDH1A1HPGDCYP1A2XBP1 | |
| SCHEMBL9242488 | 0.82 | ALDH1A1 (0.48) | ALOX15ALDH1A1HPGDCYP1A2XBP1 | |
| SCHEMBL5776615 | 0.82 | KDM4E (0.45) | ALOX15ALDH1A1HPGDLMNAMAPT | |
| SCHEMBL9573800 | 0.81 | TUBB4A (0.51) | ALOX15ALDH1A1HPGDCYP1A2XBP1 | |
| SCHEMBL1503856 | 0.80 | ALOX15 (0.81) | ALOX15ALDH1A1HPGDCYP1A2XBP1 | |
| SCHEMBL29954955 | 0.80 | ALOX15 (0.81) | ALOX15ALDH1A1HPGDCYP1A2XBP1 | |
| SCHEMBL5774466 | 0.78 | ALOX15 (0.46) | ALOX15HPGDCYP1A2CYP2C19LMNA | |
| SCHEMBL9573804 | 0.76 | ALOX15 (0.52) | ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1472221-B1 | SUBSTITUTED INDOLES, METHOD FOR PRODUCTION AND USE THEREOF FOR THE INHIBITION OF PAIN | GRUENENTHAL GMBH (DE) | 2006-03-22 | — | — | EP | disclosed |
| EP-1472221-A2 | SUBSTITUTED INDOLES, METHOD FOR PRODUCTION AND USE THEREOF FOR THE INHIBITION OF PAIN | Grünenthal GmbH (DE) | 2004-11-03 | — | — | EP | disclosed |
| WO-2003037863-A2 | SUBSTITUTED INDOLES, METHOD FOR PRODUCTION AND USE THEREOF FOR THE INHIBITION OF PAIN | Grünenthal GmbH (DE) | 2003-05-08 | — | — | WO | disclosed |