Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | CA1 | P00915 | 2/20 | 0.40 |
| ▸ | CA2 | P00918 | 2/20 | 0.40 |
| ▸ | CA9 | Q16790 | 2/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | APEX1 | P27695 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.38 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.38 |
| ▸ | GUSB | P08236 | 1/20 | 0.38 |
| ▸ | CFTR | P13569 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL583113 | 0.88 | CTSD (0.46) | MEN1KMT2AALDH1A1JAK1JAK3 | |
| SCHEMBL582321 | 0.78 | CA2 (0.54) | MEN1KMT2ACA2ALDH1A1POLB | |
| SCHEMBL581421 | 0.73 | GAA (0.55) | MEN1KMT2AALDH1A1HPGDAPEX1 | |
| SCHEMBL28811459 | 0.71 | CA2 (0.45) | MEN1KMT2ACA2ALDH1A1APEX1 | |
| SCHEMBL581713 | 0.71 | CTSD (0.43) | MEN1KMT2AALDH1A1JAK1JAK3 | |
| SCHEMBL6154491 | 0.70 | KIT (0.47) | MEN1KMT2ALMNAGAA | |
| SCHEMBL5681719 | 0.70 | GAA (0.51) | KMT2AALDH1A1HPGDPOLBLMNA | |
| SCHEMBL7866112 | 0.67 | KDM4E (0.50) | MEN1KMT2AALDH1A1POLBLMNA | |
| SCHEMBL6267577 | 0.67 | ABCB1 (0.51) | MEN1KMT2AAPEX1POLBLMNA | |
| SCHEMBL27911441 | 0.67 | MEN1 (0.41) | MEN1KMT2ALMNAHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2417130-A2 | QUINAZOLINEDIONE DERIVATIVES, PREPARATION THEREOF AND VARIOUS THERAPEUTIC USES THEREOF | SANOFI (FR) | 2012-02-15 | — | — | EP | disclosed |