Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSD | P07339 | 4/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | JAK1 | P23458 | 4/20 | 0.40 |
| ▸ | JAK3 | P52333 | 4/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | APEX1 | P27695 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL581422 | 0.88 | MEN1 (0.40) | ALDH1A1JAK1JAK3HTR2AHTR2C | |
| SCHEMBL581713 | 0.82 | CTSD (0.43) | CTSDHTTALDH1A1JAK1JAK3 | |
| SCHEMBL582321 | 0.75 | CA2 (0.54) | HTTALDH1A1GAAMEN1KMT2A | |
| SCHEMBL4582130 | 0.75 | TUBB4A (0.42) | CTSDHTTALDH1A1JAK1JAK3 | |
| SCHEMBL29229026 | 0.73 | CXCR2 (0.51) | ALDH1A1JAK1JAK3PDE4B | |
| SCHEMBL583112 | 0.73 | APEX1 (0.53) | ALDH1A1GAAMEN1KMT2ARAB9A | |
| SCHEMBL17766551 | 0.71 | JAK1 (0.53) | JAK1JAK3PDE4B | |
| SCHEMBL28811459 | 0.71 | CA2 (0.45) | HTTALDH1A1GAAMEN1KMT2A | |
| SCHEMBL6153322 | 0.70 | FLT3 (0.47) | JAK1JAK3GAAMEN1KMT2A | |
| SCHEMBL4580646 | 0.69 | CTSD (0.42) | CTSDALDH1A1JAK1JAK3MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2417130-A2 | QUINAZOLINEDIONE DERIVATIVES, PREPARATION THEREOF AND VARIOUS THERAPEUTIC USES THEREOF | SANOFI (FR) | 2012-02-15 | — | — | EP | disclosed |