Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSD | P07339 | 5/20 | 0.43 |
| ▸ | JAK1 | P23458 | 5/20 | 0.41 |
| ▸ | JAK3 | P52333 | 5/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | ATM | Q13315 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL583113 | 0.82 | CTSD (0.46) | CTSDJAK1JAK3MEN1KMT2A | |
| SCHEMBL4582130 | 0.75 | TUBB4A (0.42) | CTSDJAK1JAK3MEN1KMT2A | |
| SCHEMBL17766573 | 0.74 | JAK1 (0.47) | JAK1JAK3KCNH2ATMROCK2 | |
| SCHEMBL581712 | 0.71 | HDAC3 (0.52) | KMT2AALDH1A1MAPK1 | |
| SCHEMBL6153322 | 0.71 | FLT3 (0.47) | JAK1JAK3MEN1KMT2A | |
| SCHEMBL581422 | 0.71 | MEN1 (0.40) | JAK1JAK3MEN1KMT2AALDH1A1 | |
| SCHEMBL17766551 | 0.69 | JAK1 (0.53) | JAK1JAK3KCNH2ATMROCK2 | |
| SCHEMBL3683008 | 0.69 | PDE4B (0.47) | JAK1JAK3KCNH2ATM | |
| SCHEMBL17766577 | 0.68 | MAP2K2 (0.42) | JAK1JAK3KCNH2ATMROCK2 | |
| SCHEMBL2684142 | 0.68 | NPC1 (0.55) | CTSDHTTALDH1A1L3MBTL1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2417130-A2 | QUINAZOLINEDIONE DERIVATIVES, PREPARATION THEREOF AND VARIOUS THERAPEUTIC USES THEREOF | SANOFI (FR) | 2012-02-15 | — | — | EP | disclosed |