Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 2/20 | 0.38 |
| ▸ | HTR6 | P50406 | 4/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.31 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.30 |
| ▸ | LMNA | P02545 | 2/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | PPARG | P37231 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5785250 | 0.88 | HTR6 (0.38) | HTR6MAPK1 | |
| SCHEMBL5785930 | 0.85 | PKM (0.41) | PKMHTR6CYP2C19RXFP1ALDH1A1 | |
| SCHEMBL5786541 | 0.84 | HTR6 (0.42) | PKMHTR6CYP2C19NPY5RALDH1A1 | |
| SCHEMBL6051263 | 0.83 | HTR6 (0.43) | PKMHTR6ALDH1A1 | |
| SCHEMBL5786384 | 0.83 | HTR6 (0.35) | HTR6NPY5R | |
| SCHEMBL5786579 | 0.82 | MEN1 (0.40) | HTR6ALDH1A1LMNAPOLB | |
| SCHEMBL5781386 | 0.81 | HTR6 (0.38) | PKMHTR6RXFP1ALDH1A1LMNA | |
| SCHEMBL5786948 | 0.81 | HTR6 (0.31) | HTR6NPY5R | |
| SCHEMBL5697885 | 0.81 | LMNA (0.39) | PKMHTR6ALDH1A1LMNA | |
| SCHEMBL5785457 | 0.80 | CCR1 (0.40) | HTR6NPY5R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1648886-A1 | BENZOXAZINONE-DERIVED SULFONAMIDE COMPOUNDS, THEIR PREPARATION AND USE AS MEDICAMENTS | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2006-04-26 | — | — | EP | disclosed |
| WO-2005014589-A1 | BENZOXAZINONE-DERIVED SULFONAMIDE COMPOUNDS, THEIR PREPARATION AND USE AS MEDICAMENTS | LABORATORIOS DEL DR. ESTEVE S.A. (DE) | 2005-02-17 | — | — | WO | disclosed |