Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 6/20 | 0.42 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.33 |
| ▸ | USP2 | O75604 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.30 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5781386 | 0.91 | HTR6 (0.38) | HTR6ALDH1A1SMN1; SMN2KDM4EPKM | |
| SCHEMBL5428107 | 0.87 | HTR6 (0.47) | HTR6ALDH1A1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL5786579 | 0.86 | MEN1 (0.40) | HTR6ALDH1A1MAPTL3MBTL1 | |
| SCHEMBL6051263 | 0.85 | HTR6 (0.43) | HTR6ALDH1A1USP2PKMHSD11B1 | |
| SCHEMBL5697885 | 0.85 | LMNA (0.39) | HTR6ALDH1A1USP2MAPTGAA | |
| SCHEMBL5785250 | 0.84 | HTR6 (0.38) | HTR6SMN1; SMN2CYP2C9L3MBTL1 | |
| SCHEMBL5781878 | 0.84 | TSHR (0.44) | ALDH1A1USP2SMN1; SMN2MAPTGAA | |
| SCHEMBL5784647 | 0.84 | THRB (0.41) | HTR6HSD11B1TP53 | |
| SCHEMBL5697915 | 0.84 | HTR6 (0.37) | HTR6NPY5RALDH1A1USP2SMN1; SMN2 | |
| SCHEMBL5815922 | 0.84 | PKM (0.38) | HTR6NPY5RALDH1A1CYP2C19PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1648886-A1 | BENZOXAZINONE-DERIVED SULFONAMIDE COMPOUNDS, THEIR PREPARATION AND USE AS MEDICAMENTS | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2006-04-26 | — | — | EP | disclosed |
| WO-2005014589-A1 | BENZOXAZINONE-DERIVED SULFONAMIDE COMPOUNDS, THEIR PREPARATION AND USE AS MEDICAMENTS | LABORATORIOS DEL DR. ESTEVE S.A. (DE) | 2005-02-17 | — | — | WO | disclosed |