Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 4/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | CES2 | O00748 | 1/20 | 0.34 |
| ▸ | CES1 | P23141 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA4 | P22748 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5820869 | 0.86 | LTA4H (0.42) | ALDH1A1LMNARAB9ASMN1; SMN2MAPT | |
| SCHEMBL5820637 | 0.85 | CNR2 (0.44) | ALDH1A1RAB9AHTTSMN1; SMN2MAPT | |
| SCHEMBL5820796 | 0.85 | CYP19A1 (0.44) | ALDH1A1LMNARAB9AHTTMAPT | |
| SCHEMBL22835342 | 0.77 | PTGS1 (0.45) | ALDH1A1LMNARAB9AKDM4ENPC1 | |
| SCHEMBL4220112 | 0.71 | RAB9A (0.49) | ALDH1A1LMNARAB9ASMN1; SMN2MAPT | |
| SCHEMBL4225362 | 0.70 | RAB9A (0.67) | ALDH1A1RAB9ASMN1; SMN2MAPTKDM4E | |
| SCHEMBL15296575 | 0.69 | IDO1 (0.39) | ALDH1A1RAB9ASMN1; SMN2MAPTKDM4E | |
| SCHEMBL2086752 | 0.67 | HRH4 (0.54) | ALDH1A1LMNARAB9ASMN1; SMN2MAPT | |
| SCHEMBL15202096 | 0.66 | ALDH1A1 (0.50) | ALDH1A1LMNARAB9AHTTSMN1; SMN2 | |
| SCHEMBL21025471 | 0.65 | IDO1 (0.36) | KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006084835-A1 | N-(3-(IMIDAZO [1,5-A]PYRIMIDIN-4-YL)PHENYL]-SULFONAMIDES AND N-[3-(IMIDAZO[1,5-A]PYRIMIDIN-4-YL)-PHENYL]-CARBOXAMIDES AND THEIR USE AS GABAA RECEPTOR MODULATORS | FERRER INTERNACIONAL, S. A. (ES) | 2006-08-17 | — | — | WO | disclosed |