Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 2/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.39 |
| ▸ | QPCT | Q16769 | 1/20 | 0.39 |
| ▸ | QPCTL | Q9NXS2 | 1/20 | 0.39 |
| ▸ | CES2 | O00748 | 1/20 | 0.39 |
| ▸ | CES1 | P23141 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5816136 | 0.85 | ALDH1A1 (0.42) | LMNARAB9AMAPTHPGDALDH1A1 | |
| SCHEMBL5820869 | 0.82 | LTA4H (0.42) | RXFP1LMNANPSR1RAB9AMAPT | |
| SCHEMBL22835342 | 0.74 | PTGS1 (0.45) | LMNARAB9AMEN1KMT2AHPGD | |
| SCHEMBL19874839 | 0.72 | KMT2A (0.58) | RXFP1LMNANPSR1RAB9AMEN1 | |
| SCHEMBL15201141 | 0.69 | ALDH1A1 (0.55) | CYP19A1RXFP1LMNANPSR1RAB9A | |
| SCHEMBL8933337 | 0.68 | HPGD (0.55) | RAB9AMAPTKMT2AHPGDALDH1A1 | |
| SCHEMBL11202262 | 0.67 | SMN1; SMN2 (0.59) | RXFP1LMNANPSR1RAB9AMEN1 | |
| SCHEMBL11876573 | 0.67 | MAPT (0.50) | RXFP1LMNANPSR1RAB9AMEN1 | |
| SCHEMBL9418310 | 0.67 | RXFP1 (0.79) | RXFP1LMNANPSR1RAB9AMEN1 | |
| SCHEMBL51509 | 0.67 | RXFP1 (0.79) | RXFP1LMNANPSR1RAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006084835-A1 | N-(3-(IMIDAZO [1,5-A]PYRIMIDIN-4-YL)PHENYL]-SULFONAMIDES AND N-[3-(IMIDAZO[1,5-A]PYRIMIDIN-4-YL)-PHENYL]-CARBOXAMIDES AND THEIR USE AS GABAA RECEPTOR MODULATORS | FERRER INTERNACIONAL, S. A. (ES) | 2006-08-17 | — | — | WO | disclosed |