Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 7/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | HSD17B14 | Q9BPX1 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 6/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | CASP7 | P55210 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | CES2 | O00748 | 1/20 | 0.34 |
| ▸ | CES1 | P23141 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | CASP3 | P42574 | 1/20 | 0.34 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5816136 | 0.86 | ALDH1A1 (0.42) | NPC1RAB9AMAPTKDM4EALDH1A1 | |
| SCHEMBL5820637 | 0.85 | CNR2 (0.44) | NPC1RAB9AMAPTALDH1A1HPGD | |
| SCHEMBL22835342 | 0.77 | PTGS1 (0.45) | NPC1RAB9AKDM4EALDH1A1HPGD | |
| SCHEMBL17730235 | 0.75 | HRH4 (0.38) | MAPTTSHRCYP1A2CYP3A4KMT2A | |
| SCHEMBL8151883 | 0.69 | HSD17B14 (0.55) | LTA4HNPC1RXFP1HSD17B14MAPT | |
| SCHEMBL2086534 | 0.66 | HRH4 (0.50) | LTA4HNPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL15201354 | 0.65 | LTA4H (0.49) | LTA4HNPC1RXFP1RAB9AMAPT | |
| SCHEMBL5820871 | 0.65 | ALDH1A1 (0.40) | NPC1RAB9AMAPTALDH1A1HPGD | |
| SCHEMBL11252994 | 0.64 | LTA4H (0.56) | LTA4HNPC1RXFP1RAB9AMAPT | |
| SCHEMBL238259 | 0.63 | LTA4H (0.73) | LTA4HNPC1RXFP1RAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006084835-A1 | N-(3-(IMIDAZO [1,5-A]PYRIMIDIN-4-YL)PHENYL]-SULFONAMIDES AND N-[3-(IMIDAZO[1,5-A]PYRIMIDIN-4-YL)-PHENYL]-CARBOXAMIDES AND THEIR USE AS GABAA RECEPTOR MODULATORS | FERRER INTERNACIONAL, S. A. (ES) | 2006-08-17 | — | — | WO | disclosed |