Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 11/20 | 0.55 |
| ▸ | ROCK1 | Q13464 | 11/20 | 0.55 |
| ▸ | PRKD3 | O94806 | 3/20 | 0.48 |
| ▸ | PRKCG | P05129 | 3/20 | 0.48 |
| ▸ | PRKCB | P05771 | 3/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.48 |
| ▸ | PRKCA | P17252 | 3/20 | 0.48 |
| ▸ | PRKCH | P24723 | 3/20 | 0.48 |
| ▸ | PRKCI | P41743 | 3/20 | 0.48 |
| ▸ | PRKCE | Q02156 | 3/20 | 0.48 |
| ▸ | PRKCQ | Q04759 | 3/20 | 0.48 |
| ▸ | PRKCZ | Q05513 | 3/20 | 0.48 |
| ▸ | PRKCD | Q05655 | 3/20 | 0.48 |
| ▸ | PRKD1 | Q15139 | 3/20 | 0.48 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.48 |
| ▸ | PRKACA | P17612 | 2/20 | 0.48 |
| ▸ | PRKACG | P22612 | 2/20 | 0.48 |
| ▸ | PRKACB | P22694 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4399490 | 0.84 | HTR6 (0.62) | ROCK2ROCK1PRKD3PRKCGPRKCB | |
| SCHEMBL5426418 | 0.81 | FAAH (0.47) | EPHX2 | |
| SCHEMBL5428689 | 0.80 | ROCK2 (0.52) | ROCK2ROCK1PRKD3PRKCGPRKCB | |
| SCHEMBL5428073 | 0.80 | EPHX2 (0.43) | EPHX2HTTHTR6 | |
| SCHEMBL5436208 | 0.77 | MCOLN3 (0.51) | EPHX2MEN1KMT2A | |
| SCHEMBL5781996 | 0.76 | HTR6 (0.40) | CYP2C19EPHX2MEN1CLK1KMT2A | |
| SCHEMBL5421773 | 0.75 | MBTD1 (0.53) | CYP3A4KDM4EEPHX2MEN1KMT2A | |
| SCHEMBL5426865 | 0.75 | SMN1; SMN2 (0.45) | MEN1KMT2ASMN1; SMN2HTT | |
| SCHEMBL5441500 | 0.75 | MAPT (0.48) | KDM4EMEN1KMT2AHTT | |
| SCHEMBL5427869 | 0.75 | HTR6 (0.54) | EPHX2MEN1KMT2ASMN1; SMN2HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1648886-A1 | BENZOXAZINONE-DERIVED SULFONAMIDE COMPOUNDS, THEIR PREPARATION AND USE AS MEDICAMENTS | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2006-04-26 | — | — | EP | disclosed |
| WO-2005014589-A1 | BENZOXAZINONE-DERIVED SULFONAMIDE COMPOUNDS, THEIR PREPARATION AND USE AS MEDICAMENTS | LABORATORIOS DEL DR. ESTEVE S.A. (DE) | 2005-02-17 | — | — | WO | disclosed |