SCHEMBL581828

SCHEMBL581828

Cc1c(O)c(C)c(Br)c(C2(c3c(Br)c(C)c(O)c(C)c3Br)CCCCC2)c1Br

nearest known ligand 0.42

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
ACHE P22303 1/20 0.42
ESR1 P03372 4/20 0.35
ESR2 Q92731 4/20 0.35
ALDH1A1 P00352 1/20 0.32
TP53 P04637 1/20 0.32
CYP1A2 P05177 1/20 0.32
CYP3A4 P08684 1/20 0.32
CYP2D6 P10635 1/20 0.32
CYP2C9 P11712 1/20 0.32
HPGD P15428 1/20 0.32
ALOX15 P16050 1/20 0.32
ALOX12 P18054 1/20 0.32
CYP2C19 P33261 1/20 0.32
HIF1A Q16665 1/20 0.32
HSD17B10 Q99714 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL297789 0.80 ACHE (0.47) ACHEESR1ESR2ALOX12
SCHEMBL296660 0.80 ALDH1A1 (0.41) ACHEESR1ESR2ALDH1A1HPGD
SCHEMBL297481 0.75 ACHE (0.42) ACHEESR1ESR2
SCHEMBL581562 0.66 ESR1 (0.47) ESR1ESR2
SCHEMBL6825540 0.66 ALDH1A1 (0.46) ALDH1A1TP53CYP1A2CYP3A4CYP2D6
SCHEMBL13964608 0.66 ALDH1A1 (0.46) ALDH1A1TP53CYP1A2CYP3A4CYP2D6
SCHEMBL9171336 0.66 ALDH1A1 (0.50) ALDH1A1TP53CYP1A2CYP3A4CYP2D6
SCHEMBL846071 0.63 ALDH1A1 (0.44) ALDH1A1TP53CYP1A2CYP3A4CYP2D6
SCHEMBL11344925 0.63 ALDH1A1 (0.56) ALDH1A1TP53CYP1A2CYP3A4CYP2D6
SCHEMBL13964597 0.63 ALDH1A1 (0.44) ALDH1A1TP53CYP1A2CYP3A4CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 329 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1763560-A1 POLYARYLATE COMPOSITIONS GENERAL ELECTRIC COMPANY (US) 2007-03-21 EP claimed
US-7109274-B2 Polyarylate compositions GENERAL ELECTRIC COMPANY (US) 2006-09-19 US claimed
WO-2006012161-A1 POLYARYLATE COMPOSITIONS GENERAL ELECTRIC COMPANY (US) 2006-02-02 WO claimed
US-20060004152-A1 Polyarylate compositions GENERAL ELECTRIC COMPANY 2006-01-05 US claimed
EP-1560871-A1 METHOD FOR MAKING COPOLYCARBONATES GENERAL ELECTRIC COMPANY (US) 2005-08-10 EP claimed
WO-2004041907-A1 METHOD FOR MAKING COPOLYCARBONATES GENERAL ELECTRIC COMPANY (US) 2004-05-21 WO claimed
US-6657038-B1 Melt condensation copolymerization of dihydroxyaromatic compounds and diphenyl carbonate derivative in presence of metal hydroxide and quaternary phosphonium salt GENERAL ELECTRIC COMPANY 2003-12-02 US claimed
US-6576739-B2 Conversion of the hindered bisphenol to the corresponding bischloroformate and subsequent treatment with an amine catalyst and an aqueous base to effect polymerization by hydrolysis and condenstation of bischloroformate groups GENERAL ELECTRIC COMPANY 2003-06-10 US claimed
US-20020111456-A1 Method of polycarbonate preparation SABIC INNOVATIVE PLASTICS IP B.V. (NL) 2002-08-15 US claimed
WO-2001085825-A2 METHOD OF POLYCARBONATE PREPARATION GENERAL ELECTRIC COMPANY (US) 2001-11-15 WO claimed
US-10654973-B2 Method for producing polycarbonate SHELL OIL COMPANY (US) 2020-05-19 US disclosed
US-10640609-B2 Method for preparing a melt polycarbonate SHELL OIL COMPANY (US) 2020-05-05 US disclosed
US-10633487-B2 Inherently healing polycarbonate resins SABIC GLOBAL TECHNOLOGIES B.V. (NL) 2020-04-28 US disclosed
EP-3394149-B1 METHOD FOR PRODUCING POLYCARBONATE SHELL INT RESEARCH (NL) 2019-10-30 EP disclosed
EP-3394146-B1 METHOD FOR PREPARING A MELT POLYCARBONATE SHELL INT RESEARCH (NL) 2019-10-30 EP disclosed
US-20020111456-A1 Method of polycarbonate preparation SABIC INNOVATIVE PLASTICS IP B.V. (NL) 2002-08-15 US disclosed
US-6420512-B1 SCREW EXTRUSION AND ESTER INTERCHANGE GENERAL ELECTRIC COMPANY 2002-07-16 US disclosed
US-20020035234-A1 Continuous preparation of polycarbonate GENERAL ELECTRIC COMPANY 2002-03-21 US disclosed
WO-2002008311-A2 CONTINUOUS PREPARATION OF POLYCARBONATE GENERAL ELECTRIC COMPANY (US) 2002-01-31 WO disclosed
WO-2001085825-A2 METHOD OF POLYCARBONATE PREPARATION GENERAL ELECTRIC COMPANY (US) 2001-11-15 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10640609-B2 Method for preparing a melt polycarbonate PKD1, HSD17B7, DHCR7 ACHE 4643/4885ESR1 561/4885ESR2 1154/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.