Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Scyllitol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | APP | P05067 | 1/20 | 0.50 |
| ▸ | MGAM | O43451 | 8/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | SI | P14410 | 1/20 | 0.44 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.44 |
| ▸ | FUCA1 | P04066 | 7/20 | 0.43 |
| ▸ | GLA | P06280 | 2/20 | 0.39 |
| ▸ | GANC | Q8TET4 | 2/20 | 0.39 |
| ▸ | FUCA2 | Q9BTY2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Inositol SCHEMBL5039565 | 1.00 | ALDH1A1 (0.60) | ALDH1A1TSHRLMNAAPPMGAM | |
| Inositol SCHEMBL3835408 | 0.84 | LMNA (0.56) | ALDH1A1TSHRLMNAAPPMGAM | |
| Alcohol SCHEMBL3721594 | 0.84 | — | — | |
| Alcohol SCHEMBL28808624 | 0.78 | — | — | |
| Alcohol SCHEMBL17770701 | 0.78 | — | — | |
| Alcohol SCHEMBL9461084 | 0.78 | TSHR (1.00) | ALDH1A1TSHRLMNA | |
| Alcohol SCHEMBL2464657 | 0.78 | TSHR (1.00) | ALDH1A1TSHRLMNA | |
| Alcohol SCHEMBL54946 | 0.78 | — | — | |
| Alcohol SCHEMBL6910520 | 0.78 | TSHR (1.00) | ALDH1A1TSHRLMNA | |
| Alcohol SCHEMBL29975647 | 0.78 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9815770-B2 | Inhibitors of cognitive decline | COGNITION THERAPEUTICS, INC. (US) | 2017-11-14 | — | — | US | disclosed |
| EP-2670402-B1 | ISOLATED COMPOUNDS FROM TURMERIC OIL AND METHODS OF USE | COGNITION THERAPEUTICS INC (US) | 2017-09-20 | — | — | EP | disclosed |
| US-20170049723-A1 | ISOLATED COMPOUNDS FROM TURMERIC OIL AND METHODS OF USE | COGNITION THERAPEUTICS, INC. | 2017-02-23 | — | — | US | disclosed |
| US-20160355458-A1 | INHIBITORS OF COGNITIVE DECLINE | COGNITION THERAPEUTICS, INC. | 2016-12-08 | — | — | US | disclosed |
| US-9499462-B2 | Isolated compounds from turmeric oil and methods of use | COGNITION THERAPEUTICS, INC. (US) | 2016-11-22 | — | — | US | disclosed |
| US-9365491-B2 | Inhibitors of cognitive decline | COGNITION THERAPEUTICS, INC. (US) | 2016-06-14 | — | — | US | disclosed |
| US-20160137588-A1 | INHIBITORS OF COGNITIVE DECLINE | COGNITION THERAPEUTICS, INC. | 2016-05-19 | — | — | US | disclosed |
| US-9192585-B2 | Inhibitors of cognitive decline | COGNITION THERAPEUTICS, INC. (US) | 2015-11-24 | — | — | US | disclosed |
| EP-2458983-B1 | INHIBITORS OF COGNITIVE DECLINE | COGNITION THERAPEUTICS INC (US) | 2015-07-08 | — | — | EP | disclosed |
| EP-2416795-B1 | INHIBITORS OF COGNITIVE DECLINE | COGNITION THERAPEUTICS INC (US) | 2015-06-03 | — | — | EP | disclosed |
| WO-2012106426-A1 | ISOLATED COMPOUNDS FROM TURMERIC OIL AND METHODS OF USE | COGNITION THERAPEUTICS, INC. (US) | 2012-08-09 | — | — | WO | disclosed |
| EP-2458983-A1 | INHIBITORS OF COGNITIVE DECLINE | Cognition Therapeutics, Inc. (US) | 2012-06-06 | — | — | EP | disclosed |
| US-20120129945-A1 | INHIBITORS OF COGNITIVE DECLINE | COGNITION THERAPEUTICS, INC. (US) | 2012-05-24 | — | — | US | disclosed |
| US-20120095105-A1 | INHIBITORS OF COGNITIVE DECLINE | COGNITION THERAPEUTICS, INC. (US) | 2012-04-19 | — | — | US | disclosed |
| EP-2416795-A1 | Inhibitors of cognitive decline | Cognition Therapeutics, Inc. (US) | 2012-02-15 | — | — | EP | disclosed |
| WO-2011143587-A1 | NITRO FATTY ACIDS - NEUROPROTECTION AND/OR INHIBITION OF COGNITIVE DECLINE | NITROMEGA CORP. (US) | 2011-11-17 | — | — | WO | disclosed |
| US-20110280852-A1 | NITRO FATTY ACIDS - NEUROPROTECTION AND/OR INHIBITION OF COGNITIVE DECLINE | NITROMEGA CORP. (US) | 2011-11-17 | — | — | US | disclosed |
| WO-2011106785-A2 | METHODS OF IDENTIFYING AGENTS EFFECTIVE TO TREAT COGNITIVE DECLINE AND DISEASES ASSOCIATED THEREWITH | COGNITION THERAPEUTICS, INC. (US) | 2011-09-01 | — | — | WO | disclosed |
| WO-2011014880-A1 | INHIBITORS OF COGNITIVE DECLINE | COGNITION THERAPEUTICS, INC. (US) | 2011-02-03 | — | — | WO | disclosed |
| WO-2010118055-A1 | INHIBITORS OF COGNITIVE DECLINE | COGNITION THERAPEUTICS, INC. (US) | 2010-10-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120095105-A1 | INHIBITORS OF COGNITIVE DECLINE | PSEN2, ACHE, MAPT | ALDH1A1 3071/4885TSHR 4113/4885LMNA 3447/4885 |
| US-20120129945-A1 | INHIBITORS OF COGNITIVE DECLINE | PSEN2, ACHE, MAPT | ALDH1A1 3071/4885TSHR 4113/4885LMNA 3447/4885 |
| US-20160355458-A1 | INHIBITORS OF COGNITIVE DECLINE | PSEN2, ACHE, MAPT | ALDH1A1 3071/4885TSHR 4113/4885LMNA 3447/4885 |
| US-20170049723-A1 | ISOLATED COMPOUNDS FROM TURMERIC OIL AND METHODS OF USE | APP, MAPT, PSEN1 | ALDH1A1 3105/4885TSHR 4146/4885LMNA 3145/4885 |
| US-20110280852-A1 | NITRO FATTY ACIDS - NEUROPROTECTION AND/OR INHIBITION OF COGNITIVE DECLINE | NLN, SMN1; SMN2, CASP10 | ALDH1A1 1468/4885TSHR 4597/4885LMNA 730/4885 |
| US-20160137588-A1 | INHIBITORS OF COGNITIVE DECLINE | PSEN2, ACHE, MAPT | ALDH1A1 3071/4885TSHR 4113/4885LMNA 3447/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.