Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.73 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.63 |
| ▸ | MEN1 | O00255 | 6/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.62 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.62 |
| ▸ | RELA | Q04206 | 1/20 | 0.62 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | MAOB | P27338 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28358559 | 0.88 | PTGS2 (0.68) | POLBPTGS2KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL11250330 | 0.85 | POLB (1.00) | POLBPTGS2KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL30511886 | 0.83 | POLB (0.97) | POLBPTGS2KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL28358360 | 0.83 | PTGS2 (0.94) | POLBPTGS2KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL28358558 | 0.83 | POLB (0.76) | POLBPTGS2KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL3447906 | 0.82 | PTGS2 (1.00) | POLBPTGS2KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL11244220 | 0.82 | PTGS2 (0.71) | POLBPTGS2KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL30511902 | 0.82 | PTGS2 (0.71) | POLBPTGS2KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL23392558 | 0.82 | PTGS2 (0.86) | POLBPTGS2KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL10579042 | 0.82 | PTGS2 (0.80) | POLBPTGS2KMT2AALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11548875-B2 | Inhibitor compounds for male contraception | UNIVERSITY OF WASHINGTON (US) | 2023-01-10 | — | — | US | disclosed |
| US-20210332030-A1 | INHIBITOR COMPOUNDS FOR MALE CONTRACEPTION | UNIVERSITY OF WASHINGTON (US) | 2021-10-28 | — | — | US | disclosed |
| WO-2006033995-A2 | THIAZOLIDIN-4-ONES HAVING ANTI-HEPATITIS B ACTIVITY | VALEANT RESEARCH AND DEVELOPMENT (US) | 2006-03-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210332030-A1 | INHIBITOR COMPOUNDS FOR MALE CONTRACEPTION | ALDH1A1, ALDH3A1, ALDH16A1 | POLB 1596/4885PTGS2 908/4885KMT2A 1384/4885 |
| US-11548875-B2 | Inhibitor compounds for male contraception | ALDH1A1, ALDH3A1, ALDH16A1 | POLB 1596/4885PTGS2 908/4885KMT2A 1384/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.