Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 1/20 | 0.61 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.50 |
| ▸ | APP | P05067 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | RET | P07949 | 1/20 | 0.40 |
| ▸ | FLT1 | P17948 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | RAB9A | P51151 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | METAP2 | P50579 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | COMT | P21964 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | METAP1 | P53582 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3622776 | 0.80 | PDPK1 (0.61) | PDPK1DYRK1AAPPACHERET | |
| SCHEMBL6544062 | 0.79 | PDPK1 (0.66) | PDPK1DYRK1AAPPACHERET | |
| SCHEMBL17987894 | 0.76 | PDPK1 (0.61) | PDPK1DYRK1AAPPACHERET | |
| SCHEMBL5432001 | 0.76 | PDPK1 (0.61) | PDPK1DYRK1AAPPACHERET | |
| SCHEMBL74065 | 0.76 | PDPK1 (1.00) | PDPK1DYRK1AAPPACHERET | |
| SCHEMBL5339377 | 0.76 | ALDH1A1 (0.61) | ALDH1A1RAB9AKMT2AGAATSHR | |
| SCHEMBL6692558 | 0.76 | LMNA (0.61) | ALDH1A1RAB9AKMT2AGAATSHR | |
| SCHEMBL29951795 | 0.74 | PDPK1 (0.59) | PDPK1DYRK1AAPPACHERET | |
| SCHEMBL24287678 | 0.73 | PDPK1 (0.58) | PDPK1DYRK1AAPPACHERET | |
| SCHEMBL483414 | 0.72 | APP (0.68) | PDPK1DYRK1AAPPRETFLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006089311-A1 | VANILLOID RECEPTOR LIGANDS AND THEIR USE IN TREATMENTS | AMGEN INC. (US) | 2006-08-24 | — | — | WO | disclosed |