Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 12/20 | 0.55 |
| ▸ | DRD3 | P35462 | 5/20 | 0.55 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | CCR1 | P32246 | 1/20 | 0.51 |
| ▸ | DRD4 | P21917 | 2/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.47 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.47 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.47 |
| ▸ | HTR1A | P08908 | 2/20 | 0.47 |
| ▸ | DRD1 | P21728 | 2/20 | 0.47 |
| ▸ | DRD5 | P21918 | 2/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.47 |
| ▸ | HTR2A | P28223 | 2/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.47 |
| ▸ | HTR7 | P34969 | 2/20 | 0.47 |
| ▸ | HRH1 | P35367 | 2/20 | 0.47 |
| ▸ | HTR2B | P41595 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23883211 | 1.00 | DRD2 (0.55) | DRD2DRD3SIGMAR1LMNACCR1 | |
| SCHEMBL16992739 | 0.84 | DRD2 (0.60) | DRD2DRD3SIGMAR1LMNACCR1 | |
| SCHEMBL5323013 | 0.82 | DRD2 (0.43) | DRD2DRD3SIGMAR1LMNACCR1 | |
| SCHEMBL4053894 | 0.81 | DRD2 (0.54) | DRD2DRD3SIGMAR1LMNACCR1 | |
| Hydrochloric Acid SCHEMBL20271390 | 0.80 | DRD2 (0.53) | DRD2DRD3SIGMAR1LMNACCR1 | |
| SCHEMBL4003607 | 0.79 | OPRM1 (0.48) | DRD2DRD3LMNACCR1OPRM1 | |
| SCHEMBL10677826 | 0.74 | OPRL1 (0.37) | DRD2DRD3DRD4OPRM1OPRD1 | |
| SCHEMBL11399201 | 0.73 | P2RX7 (0.37) | LMNAOPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL11716220 | 0.72 | DRD2 (0.62) | DRD2DRD3SIGMAR1LMNACCR1 | |
| SCHEMBL11716222 | 0.72 | DRD2 (0.62) | DRD2DRD3SIGMAR1LMNACCR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006050511-A2 | BUTYROPHENOMENES AND SIGMA-1 RECEPTOR ANTAGONISTS PROTECT AGAINST OXIDATIVES-STRESS | UNIVERSITY OF NORTH TEXAS HEALTH SCIENCE CENTER AT FORT WORTH (US) | 2006-05-11 | — | — | WO | disclosed |
| WO-2005053663-A2 | NOREPINEPHRINE REUPTAKE INHIBITORS USEFUL FOR TREATMENT OF COGNITIVE FAILURE | ELI LILLY AND COMPANY (US) | 2005-06-16 | — | — | WO | disclosed |
| EP-0031561-A2 | A rectally administered suppository comprising a drug and an adjuvant | MERCK & CO. INC. (US) | 1981-07-08 | — | — | EP | disclosed |