Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.58 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.58 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.58 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.58 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.58 |
| ▸ | EIF4H | Q15056 | 1/20 | 0.58 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 2/20 | 0.57 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.57 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.57 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.57 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.53 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.53 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.53 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 5/20 | 0.52 |
| ▸ | GAA | P10253 | 4/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7299760 | 0.90 | MEN1 (0.59) | MEN1KMT2APABPC1DUSP3PTPN5 | |
| SCHEMBL8129874 | 0.88 | KMT2A (0.58) | MEN1KMT2ARAB9ACXCR1CXCR2 | |
| SCHEMBL447659 | 0.85 | MEN1 (0.58) | MEN1KMT2APABPC1DUSP3PTPN5 | |
| SCHEMBL28117177 | 0.80 | LMNA (0.60) | MEN1KMT2APABPC1DUSP3PTPN5 | |
| SCHEMBL1024223 | 0.80 | CXCR2 (0.68) | MEN1KMT2APABPC1DUSP3PTPN5 | |
| SCHEMBL1024222 | 0.80 | CXCR2 (0.68) | MEN1KMT2APABPC1DUSP3PTPN5 | |
| 2-Amino-4-Nitrophenol SCHEMBL6224982 | 0.79 | GAA (0.60) | MEN1KMT2APABPC1DUSP3PTPN5 | |
| SCHEMBL915213 | 0.78 | MEN1 (0.64) | MEN1KMT2APABPC1DUSP3PTPN5 | |
| SCHEMBL5391358 | 0.78 | KMT2A (0.67) | MEN1KMT2APABPC1DUSP3PTPN5 | |
| SCHEMBL6510957 | 0.78 | SMN1; SMN2 (0.64) | MEN1KMT2APABPC1DUSP3PTPN5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015047124-A1 | NOVEL CHEMICAL COMPOUNDS DERIVED FROM 2,4-DIAMINO-1,3,5-TRIAZINE FOR THE PROPHYLAXIS AND TREATMENT OF HUMAN AND ANIMAL DISEASES | Общество с ограниченной ответственностью "Молекулярные Технологии" | 2015-04-02 | — | — | WO | disclosed |
| US-20130281446-A1 | XINAFOATE SALT OF N4-(2,2-DIFLUORO-4H-BENZO[1,4]OXAZIN-3-ONE)-6-YL]-5-FLUORO-N2-[3-(METHYLAMINOCARBONYLMETHYLENEOXY)PHENYL]2,4-PYRIMIDINEDIAMINE | RIGEL PHARMACEUTICALS, INC. | 2013-10-24 | — | — | US | disclosed |
| US-8486935-B2 | Xinafoate salt of N4-(2,2-difluoro-4H-benzo[1,4]oxazin-3-one)-6-yl]-5-fluoro-N2-[3-(methylaminocarbonylmethyleneoxy)phenyl]2,4-pyrimidinediamine | RIGEL PHARMACEUTICALS, INC. (US) | 2013-07-16 | — | — | US | disclosed |
| WO-2013059631-A1 | METHOD AND DEVICE FOR ADMINISTERING XINAFOATE SALT OF N4-(2,2-DIFLUORO-4H-BENZO [1,4] OXAZIN-3-ONE) -6-YL] -5-FLUORO-N2- [3- (METHYLAMINOCARBONYLMETHYLENEOXY) PHENYL] 2,4-PYRIMIDINEDIAMINE | RIGEL PHARMACEUTICALS, INC. (US) | 2013-04-25 | — | — | WO | disclosed |
| US-20130102596-A1 | METHOD AND DEVICE FOR ADMINISTERING XINAFOATE SALT OF N4-(2,2-DIFLUORO-4H-BENZO [1,4]OXAZIN-3-ONE)-6-YL]-5-FLUORO-N2-[3- (METHYLAMINOCARBONYLMETHYLENEOXY) PHENYL]2,4-PYRIMIDINEDIAMINE | RIGEL PHARMACEUTICALS, INC. (US) | 2013-04-25 | — | — | US | disclosed |
| US-8193181-B2 | Xinafoate salt of N4-(2,2-difluoro-4H-benzo[1,4]oxazin-3-one)-6-yl]-5-fluoro-N2-[3-(methylaminocarbonylmethyleneoxy) phenyl]2,4-pyrimidinediamine | RIGEL PHARMACEUTICALS, INC. (US) | 2012-06-05 | — | — | US | disclosed |
| US-20100204232-A1 | XINAFOATE SALT OF N4-(2,2-DIFLUORO-4H-BENZ0 [1,4] OXAZIN-3-ONE) -6-YL] -5-FLUORO-N2- [3-(METHYLAMINOCAR BONYLMETHYLENEOXY) PHENYL] 2,4-PYRIMIDINEDIAMINE | MIDCAP FINANCIAL TRUST | 2010-08-12 | — | — | US | disclosed |
| WO-2006129100-A1 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2006-12-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100204232-A1 | XINAFOATE SALT OF N4-(2,2-DIFLUORO-4H-BENZ0 [1,4] OXAZIN-3-ONE) -6-YL] -5-FLUORO-N2- [3-(METHYLAMINOCAR BONYLMETHYLENEOXY) PHENYL] 2,4-PYRIMIDINEDIAMINE | HRH4, P2RY10, KCNN4 | MEN1 3005/4885KMT2A 690/4885PABPC1 2708/4885 |
| US-20130102596-A1 | METHOD AND DEVICE FOR ADMINISTERING XINAFOATE SALT OF N4-(2,2-DIFLUORO-4H-BENZO [1,4]OXAZIN-3-ONE)-6-YL]-5-FLUORO-N2-[3- (METHYLAMINOCARBONYLMETHYLENEOXY) PHENYL]2,4-PYRIMIDINEDIAMINE | YTHDF1, YTHDF2, YTHDF3 | MEN1 2883/4885KMT2A 1105/4885PABPC1 2331/4885 |
| US-20130281446-A1 | XINAFOATE SALT OF N4-(2,2-DIFLUORO-4H-BENZO[1,4]OXAZIN-3-ONE)-6-YL]-5-FLUORO-N2-[3-(METHYLAMINOCARBONYLMETHYLENEOXY)PHENYL]2,4-PYRIMIDINEDIAMINE | P2RY4, KCNN4, KCNJ4 | MEN1 3663/4885KMT2A 953/4885PABPC1 2208/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.