Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 2/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 8/20 | 0.39 |
| ▸ | KIF11 | P52732 | 2/20 | 0.36 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | MAP1LC3B | Q9GZQ8 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5864291 | 0.88 | TDP1 (0.42) | PTGS1PTGS2TDP1MAPK8KIF11 | |
| SCHEMBL5864327 | 0.77 | CYP2C19 (0.40) | PTGS1PTGS2TDP1MAPK8KIF11 | |
| SCHEMBL5754107 | 0.76 | ALDH1A1 (0.41) | PTGS1PTGS2TDP1MAPK8KIF11 | |
| SCHEMBL5863779 | 0.75 | TDP1 (0.36) | PTGS1PTGS2TDP1MAPK8KIF11 | |
| SCHEMBL5786959 | 0.74 | L3MBTL1 (0.37) | PTGS1PTGS2TDP1MAPK8KIF11 | |
| SCHEMBL5752888 | 0.74 | KIF11 (0.41) | PTGS1PTGS2TDP1MAPK8KIF11 | |
| SCHEMBL4510476 | 0.74 | KIF11 (0.46) | PTGS1PTGS2TDP1MAPK8KIF11 | |
| SCHEMBL5863739 | 0.74 | MAPK8 (0.38) | PTGS1PTGS2TDP1MAPK8KIF11 | |
| SCHEMBL5863996 | 0.74 | ALDH1A1 (0.39) | MAPK8MAPTCYP3A4CYP2C19KDM4E | |
| SCHEMBL5754034 | 0.73 | GRIN1 (0.39) | PTGS1PTGS2TDP1MAPK8CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1556357-A4 | COMPOUNDS, COMPOSITIONS, AND METHODS | CYTOKINETICS INC (US) | 2006-09-13 | — | — | EP | disclosed |
| EP-1556357-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS | Cytokinetics, Inc. (US) | 2005-07-27 | — | — | EP | disclosed |
| WO-2003106426-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS | CYTOKINETICS, INC. (US) | 2003-12-24 | — | — | WO | disclosed |