Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 5/20 | 0.36 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.34 |
| ▸ | PDE1C | Q14123 | 4/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.33 |
| ▸ | MAP1LC3B | Q9GZQ8 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | KIF11 | P52732 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5754107 | 0.91 | ALDH1A1 (0.41) | TDP1PTGS1PTGS2MAPK8MAPK9 | |
| SCHEMBL5864327 | 0.90 | CYP2C19 (0.40) | TDP1PTGS1PTGS2MAPK8MAPK9 | |
| SCHEMBL5786959 | 0.89 | L3MBTL1 (0.37) | TDP1PTGS1PTGS2MAPK8MAPT | |
| SCHEMBL5752888 | 0.89 | KIF11 (0.41) | TDP1PTGS1PTGS2MAPK8MAP1LC3B | |
| SCHEMBL5864191 | 0.89 | PDE4A (0.39) | TDP1PTGS1PTGS2MAPT | |
| SCHEMBL5863739 | 0.89 | MAPK8 (0.38) | TDP1PTGS1PTGS2MAPK8PDE1C | |
| SCHEMBL5863996 | 0.89 | ALDH1A1 (0.39) | MAPK8MAPTTP53CYP3A4CYP2C19 | |
| SCHEMBL5754034 | 0.87 | GRIN1 (0.39) | TDP1PTGS1PTGS2MAPK8TP53 | |
| SCHEMBL4517621 | 0.87 | KIF11 (0.43) | TDP1PTGS1PTGS2MAP1LC3BCYP3A4 | |
| SCHEMBL5864291 | 0.85 | TDP1 (0.42) | TDP1PTGS1PTGS2MAPK8MAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7041676-B2 | Compounds, compositions, and methods | CYTOKINETICS, INC. (US) | 2006-05-09 | — | — | US | disclosed |
| US-20060019988-A1 | Compounds for treating cell prolifieration disease with of kinesin activity , anticancer activity | CYTOKINETICS, INC. | 2006-01-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060019988-A1 | Compounds for treating cell prolifieration disease with of kinesin activity , anticancer activity | KIF5B, KIF2C, KIF18A | TDP1 554/4885PTGS1 2664/4885PTGS2 3010/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.