Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | PRKCB | P05771 | 1/20 | 0.36 |
| ▸ | PRKCA | P17252 | 1/20 | 0.36 |
| ▸ | PRKCH | P24723 | 1/20 | 0.36 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.36 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.36 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.34 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.32 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.32 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.32 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6327624 | 0.83 | PIM1 (0.41) | PRKCBPRKCAPRKCHPRKCEPRKCQ | |
| SCHEMBL5802080 | 0.83 | PIM1 (0.41) | PRKCBPRKCAPRKCHPRKCEPRKCQ | |
| SCHEMBL5787181 | 0.76 | ALDH1A1 (0.48) | PRKCBPRKCAPRKCHPRKCEPRKCQ | |
| SCHEMBL6335744 | 0.74 | ADORA2A (0.43) | SCN9AADORA2APIM1 | |
| SCHEMBL6330871 | 0.74 | ADORA2A (0.43) | SCN9AADORA2APIM1 | |
| SCHEMBL6329198 | 0.73 | NTRK1 (0.43) | PRKCBPRKCAPRKCHPRKCEPRKCQ | |
| SCHEMBL6337012 | 0.73 | NTRK1 (0.43) | PRKCBPRKCAPRKCHPRKCEPRKCQ | |
| SCHEMBL6334984 | 0.73 | NTRK1 (0.43) | PRKCBPRKCAPRKCHPRKCEPRKCQ | |
| SCHEMBL5785657 | 0.72 | L3MBTL1 (0.42) | SCN9AADORA2AHTR2A | |
| SCHEMBL5789600 | 0.71 | BPTF (0.43) | SCN9APTPN11ADORA2AHTR6PIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1685115-A1 | NOVEL NOREPINEPHRINE REUPTAKE INHIBITORS FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS | Warner-Lambert Company LLC (US) | 2006-08-02 | — | — | EP | disclosed |
| WO-2005042501-A1 | NOVEL NOREPINEPHRINE REUPTAKE INHIBITORS FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS | WARNER-LAMBERT COMPANY LLC (US) | 2005-05-12 | — | — | WO | disclosed |