Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.50 |
| ▸ | GAA | P10253 | 3/20 | 0.50 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.50 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 5/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | CXCR5 | P32302 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL503962 | 0.80 | ALDH1A1 (0.61) | ALDH1A1KDM4ELMNATP53RAB9A | |
| SCHEMBL30393029 | 0.80 | ALDH1A1 (0.61) | ALDH1A1KDM4ELMNATP53RAB9A | |
| Hydrochloric Acid SCHEMBL1037379 | 0.79 | ALDH1A1 (0.60) | ALDH1A1KDM4ELMNATP53RAB9A | |
| SCHEMBL10751607 | 0.78 | TLR8 (0.59) | ALDH1A1KDM4EGAATLR8PDE10A | |
| SCHEMBL16588903 | 0.77 | TLR8 (0.59) | ALDH1A1KDM4EGAATLR8LMNA | |
| SCHEMBL27546694 | 0.77 | PDE10A (0.49) | ALDH1A1KDM4EGAAPDE10ALMNA | |
| SCHEMBL27993510 | 0.76 | ALOX15 (0.49) | ALDH1A1KDM4EGAATLR8LMNA | |
| SCHEMBL9422350 | 0.75 | NPC1 (0.49) | ALDH1A1KDM4EGAAPDE10ALMNA | |
| SCHEMBL6532788 | 0.74 | MAPT (0.48) | ALDH1A1GAALMNARAB9ANPC1 | |
| SCHEMBL12471647 | 0.74 | ALDH1A1 (0.45) | ALDH1A1KDM4EGAAPDE10ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006040650-A1 | 4-METHOXYACRIDINE-1-CARBOXAMIDE DERIVATIVES AND THE PHENAZINE AND OXANTHRENE ANALOGS AS PDE4-INHIBITORS FOR THE TREATMENT OF ASTHMA AND CHRONIC PULMONARY DISEASE (COPD) | GLENMARK PHARMACEUTICALS S.A. (US) | 2006-04-20 | — | — | WO | disclosed |