Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | SLC28A3 | Q9HAS3 | 2/20 | 0.41 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.41 |
| ▸ | LGALS3 | P17931 | 2/20 | 0.41 |
| ▸ | LGALS9 | O00182 | 1/20 | 0.41 |
| ▸ | LGALS1 | P09382 | 1/20 | 0.41 |
| ▸ | LGALS7; LGALS7B | P47929 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LGALS4 | P56470 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 3/20 | 0.39 |
| ▸ | CA9 | Q16790 | 3/20 | 0.39 |
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | TYR | P14679 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29278300 | 0.82 | LGALS3 (0.51) | SLC28A3SLC5A2LGALS3LGALS9LGALS1 | |
| SCHEMBL6739168 | 0.82 | LGALS3 (0.51) | SLC28A3SLC5A2LGALS3LGALS9LGALS1 | |
| Hydrochloric Acid SCHEMBL28792398 | 0.81 | LGALS3 (0.50) | SLC28A3SLC5A2LGALS3LGALS9LGALS1 | |
| SCHEMBL19717962 | 0.79 | LGALS9 (0.46) | SLC28A3LGALS3LGALS9LGALS1LGALS7; LGALS7B | |
| Ribose (Furanose) SCHEMBL5827542 | 0.79 | TDP1 (0.44) | SIRT3TDP1SLC5A2MEN1KMT2A | |
| SCHEMBL25333021 | 0.78 | ALDH1A1 (0.46) | TDP1SLC28A3LGALS3LGALS9LGALS1 | |
| SCHEMBL21828727 | 0.78 | ALDH1A1 (0.46) | TDP1SLC28A3LGALS3LGALS9LGALS1 | |
| SCHEMBL29993128 | 0.78 | ALDH1A1 (0.46) | TDP1SLC28A3LGALS3LGALS9LGALS1 | |
| SCHEMBL25387949 | 0.78 | ALDH1A1 (0.46) | TDP1SLC28A3LGALS3LGALS9LGALS1 | |
| SCHEMBL502585 | 0.78 | ALDH1A1 (0.46) | TDP1SLC28A3LGALS3LGALS9LGALS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0638123-B1 | BACTERIAL NITROREDUCTASE FOR THE REDUCTION OF CB 1954 AND ANALOGUES THEREOF TO A CYTOTOXIC FORM | CANCER REC TECH LTD (GB) | 2006-12-27 | — | — | EP | disclosed |
| US-5977065-A | FROM A PRODRUG | CANCER RESEARCH CAMPAIGN TECHNOLOGY LIMITED (GB) | 1999-11-02 | — | — | US | disclosed |
| US-5780585-A | Bacterial nitroreductase for the reduction of CB 1954 and analogues thereof to a cytotoxic form | CANCER RESEARCH CAMPAIGN TECHNOLOGY LIMITED (GB) | 1998-07-14 | — | — | US | disclosed |
| US-5633158-A | CULTURE PRODUCT; GENETIC ENGINEERING | CANCER RESEARCH CAMPAIGN TECHNOLOGY LIMITED (GB) | 1997-05-27 | — | — | US | disclosed |
| EP-0638123-A1 | BACTERIAL NITROREDUCTASE FOR THE REDUCTION OF CB 1954 AND ANALOGUES THEREOF TO A CYTOTOXIC FORM | CANCER RESEARCH CAMPAIGN TECHNOLOGY LIMITED (GB) | 1995-02-15 | — | — | EP | disclosed |
| EP-0540263-A1 | Bacterial nitroreductase for the reduction of CB 1954 and analogues thereof to a cytotoxic form | CANCER RESEARCH CAMPAIGN TECHNOLOGY LIMITED (GB) | 1993-05-05 | — | — | EP | disclosed |
| WO-1993008288-A1 | BACTERIAL NITROREDUCTASE FOR THE REDUCTION OF CB 1954 AND ANALOGUES THEREOF TO A CYTOTOXIC FORM | CANCER RESEARCH CAMPAIGN TECHNOLOGY LIMITED (GB) | 1993-04-29 | — | — | WO | disclosed |