SCHEMBL5828417

SCHEMBL5828417

CO[C@H]1[C@@H](O)[C@H](n2cnc3c(=O)[nH]c(N)nc32)O[C@@H]1COP(=O)(O)O

nearest known ligand 0.68

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
NT5E P21589 1/20 0.68
IMPDH2 P12268 7/20 0.68
IMPDH1 P20839 2/20 0.68
TAS1R3 Q7RTX0 2/20 0.64
TAS1R1 Q7RTX1 2/20 0.64
TGM2 P21980 1/20 0.63
FUT5 Q11128 1/20 0.59
HINT1 P49773 1/20 0.59
KRAS P01116 6/20 0.58
CA5A P35218 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10037916 1.00 NT5E (0.68) NT5EIMPDH2IMPDH1TAS1R3TAS1R1
SCHEMBL10067882 1.00 NT5E (0.68) NT5EIMPDH2IMPDH1TAS1R3TAS1R1
SCHEMBL13638722 1.00 NT5E (0.68) NT5EIMPDH2IMPDH1TAS1R3TAS1R1
SCHEMBL9976681 1.00 NT5E (0.68) NT5EIMPDH2IMPDH1TAS1R3TAS1R1
SCHEMBL5827788 0.93 TGM2 (0.69) NT5EIMPDH2IMPDH1TAS1R3TAS1R1
SCHEMBL5827796 0.93 TGM2 (0.69) NT5EIMPDH2IMPDH1TAS1R3TAS1R1
SCHEMBL25070726 0.93 TGM2 (0.66) NT5EIMPDH2IMPDH1TAS1R3TAS1R1
SCHEMBL29092996 0.93 NT5E (0.66) NT5EIMPDH2IMPDH1TAS1R3TAS1R1
SCHEMBL720437 0.93 TAS1R3 (0.70) NT5EIMPDH2IMPDH1TAS1R3TAS1R1
SCHEMBL14576179 0.93 TAS1R3 (0.70) NT5EIMPDH2IMPDH1TAS1R3TAS1R1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 40 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4717779-A2 COMPOSITIONS AND METHODS FOR SYNTHESIZING 5'-CAPPED RNAS TriLink BioTechnologies, LLC (US) 2026-04-01 EP disclosed
EP-4276189-B1 INITIATING CAPPED OLIGONUCLEOTIDE PRIMERS FOR SYNTHESIZING 5'-CAPPED RNAS TRILINK BIOTECHNOLOGIES LLC (US) 2026-04-01 EP disclosed
EP-4424835-B1 COMPOSITIONS AND METHODS FOR SYNTHESIZING 5'-CAPPED RNAS TRILINK BIOTECHNOLOGIES LLC (US) 2026-01-21 EP disclosed
EP-4658772-A1 IN VITRO TRANSCRIPTION METHODS AND COMPOUNDS FOR USE THEREIN Genscript USA Inc. (US) 2025-12-10 EP disclosed
US-20250171489-A1 COMPOSITIONS AND METHODS FOR SYNTHESIZING 5'-CAPPED RNAS TRILINK BIOTECHNOLOGIES, LLC (US) 2025-05-29 US disclosed
US-12258369-B2 Compositions and methods for synthesizing 5′-capped RNAs TRILINK BIOTECHNOLOGIES, LLC (US) 2025-03-25 US disclosed
US-12103944-B2 Compositions and methods for synthesizing 5′-capped RNAs TRILINK BIOTECHNOLOGIES, LLC (US) 2024-10-01 US disclosed
EP-4424835-A2 COMPOSITIONS AND METHODS FOR SYNTHESIZING 5'-CAPPED RNAS TriLink BioTechnologies, LLC (US) 2024-09-04 EP disclosed
WO-2024163689-A1 IN VITRO TRANSCRIPTION METHODS AND COMPOUNDS FOR USE THEREIN GENSCRIPT USA INC. (US) 2024-08-08 WO disclosed
US-20240158433-A1 COMPOSITIONS AND METHODS FOR SYNTHESIZING 5'-CAPPED RNAS TRILINK BIOTECHNOLOGIES, LLC (US) 2024-05-16 US disclosed
EP-3352584-B1 COMPOSITIONS AND METHODS FOR SYNTHESIZING 5'-CAPPED RNAS TRILINK BIOTECHNOLOGIES LLC (US) 2021-05-12 EP disclosed
US-10913768-B2 Compositions and methods for synthesizing 5′-capped RNAs TRILINK BIOTECHNOLOGIES, INC. (US) 2021-02-09 US disclosed
US-10519189-B2 Compositions and methods for synthesizing 5′-Capped RNAs TRILINK BIOTECHNOLOGIES, INC. (US) 2019-12-31 US disclosed
US-10494399-B2 Compositions and methods for synthesizing 5′-Capped RNAS TRILINK BIOTECHNOLOGIES, INC. (US) 2019-12-03 US disclosed
US-20190270766-A1 COMPOSITIONS AND METHODS FOR SYNTHESIZING 5'-CAPPED RNAS TRILINK BIOTECHNOLOGIES, INC. (US) 2019-09-05 US disclosed
US-20190144490-A1 COMPOSITIONS AND METHODS FOR SYNTHESIZING 5'-CAPPED RNAS TRILINK BIOTECHNOLOGIES, INC. (US) 2019-05-16 US disclosed
US-20180273576-A1 COMPOSITIONS AND METHODS FOR SYNTHESIZING 5'-CAPPED RNAS TRILINK BIOTECHNOLOGIES, INC. (US) 2018-09-27 US disclosed
US-20060252115-A1 Synthesis and use of anti-reverse mRNA cap analogues DARZYNKIEWICZ EDWARD 2006-11-09 US disclosed
US-7074596-B2 Synthesis and use of anti-reverse mRNA cap analogues BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE (US) 2006-07-11 US disclosed
US-20030194759-A1 Synthesis and use of anti-reverse mRBA cap analogues DARZYNKIEWICZ, EDWARD (PL) 2003-10-16 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060252115-A1 Synthesis and use of anti-reverse mRNA cap analogues RNGTT, RNMT, CPSF6 NT5E 486/4885IMPDH2 861/4885IMPDH1 640/4885
US-12258369-B2 Compositions and methods for synthesizing 5′-capped RNAs RNGTT, RNMT, NT5C3B NT5E 32/4885IMPDH2 266/4885IMPDH1 224/4885
US-10494399-B2 Compositions and methods for synthesizing 5′-Capped RNAS RNGTT, RNMT, NT5C3B NT5E 32/4885IMPDH2 266/4885IMPDH1 224/4885
US-20180273576-A1 COMPOSITIONS AND METHODS FOR SYNTHESIZING 5'-CAPPED RNAS RNGTT, RNMT, NT5C3B NT5E 29/4885IMPDH2 262/4885IMPDH1 218/4885
US-10913768-B2 Compositions and methods for synthesizing 5′-capped RNAs RNGTT, RNMT, NT5C3B NT5E 32/4885IMPDH2 266/4885IMPDH1 224/4885
US-10519189-B2 Compositions and methods for synthesizing 5′-Capped RNAs RNGTT, RNMT, NT5C3B NT5E 32/4885IMPDH2 266/4885IMPDH1 224/4885
US-12103944-B2 Compositions and methods for synthesizing 5′-capped RNAs RNGTT, RNMT, NT5C3B NT5E 32/4885IMPDH2 266/4885IMPDH1 224/4885
US-20250171489-A1 COMPOSITIONS AND METHODS FOR SYNTHESIZING 5'-CAPPED RNAS RNGTT, RNMT, NT5C3B NT5E 29/4885IMPDH2 262/4885IMPDH1 218/4885
US-20190144490-A1 COMPOSITIONS AND METHODS FOR SYNTHESIZING 5'-CAPPED RNAS RNGTT, RNMT, NT5C3B NT5E 29/4885IMPDH2 262/4885IMPDH1 218/4885
US-20240158433-A1 COMPOSITIONS AND METHODS FOR SYNTHESIZING 5'-CAPPED RNAS RNGTT, RNMT, NT5C3B NT5E 29/4885IMPDH2 262/4885IMPDH1 218/4885
US-20190270766-A1 COMPOSITIONS AND METHODS FOR SYNTHESIZING 5'-CAPPED RNAS RNGTT, RNMT, NT5C3B NT5E 29/4885IMPDH2 262/4885IMPDH1 218/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.