Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | LTA4H | P09960 | 2/20 | 0.45 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.45 |
| ▸ | ATP4A | P20648 | 3/20 | 0.45 |
| ▸ | ATP4B | P51164 | 3/20 | 0.45 |
| ▸ | ACHE | P22303 | 1/20 | 0.45 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HTR1D | P28221 | 3/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5828525 | 0.87 | SIRT2 (0.59) | MAPTSIRT2MEN1KMT2AALDH1A1 | |
| SCHEMBL5339384 | 0.85 | HTR1D (0.48) | TRPM8KDM4EMAPTLTA4HPLA2G2A | |
| SCHEMBL5337023 | 0.79 | MAOA (0.52) | TRPM8KDM4EMAPTLTA4HPLA2G2A | |
| SCHEMBL5828027 | 0.79 | PIM1 (0.47) | SIRT2 | |
| SCHEMBL9374063 | 0.79 | SIRT2 (0.70) | MAPTSIRT2MEN1KMT2A | |
| Tert-Butyl Formate SCHEMBL27613248 | 0.78 | ACHE (0.43) | TRPM8KDM4EMAPTLTA4HPLA2G2A | |
| SCHEMBL7814978 | 0.78 | MAOA (0.58) | TRPM8KDM4EMAPTLTA4HPLA2G2A | |
| SCHEMBL5332724 | 0.77 | ALDH1A1 (0.52) | TRPM8KDM4EMAPTACHESIRT2 | |
| SCHEMBL7815290 | 0.75 | PRKCB (0.60) | TRPM8KDM4EMAPTLTA4HPLA2G2A | |
| SCHEMBL7828332 | 0.75 | TRPM8 (0.53) | TRPM8KDM4EMAPTLTA4HPLA2G2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1646380-A4 | INDOLOCARBAZOLE ANTICANCER AGENTS AND METHODS OF USING SAME | ADVANCED LIFE SCIENCES INC (US) | 2009-03-11 | — | — | EP | disclosed |
| US-7122526-B2 | Indolocarbazole anticancer agents and methods of using same | NANOSPHERE, INC. (US) | 2006-10-17 | — | — | US | disclosed |
| EP-1646380-A2 | INDOLOCARBAZOLE ANTICANCER AGENTS AND METHODS OF USING SAME | Advanced Life Sciences Inc. (US) | 2006-04-19 | — | — | EP | disclosed |
| EP-1341412-B1 | INDOLOCARBAZOLE ANTICANCER AGENTS AND METHODS OF USING THEM | ADVANCED LIFE SCIENCES INC (US) | 2006-01-11 | — | — | EP | disclosed |
| WO-2005039484-A2 | INDOLOCARBAZOLE ANTICANCER AGENTS AND METHODS OF USING SAME | ADVANCED LIFE SCIENCES, INC. (US) | 2005-05-06 | — | — | WO | disclosed |
| US-20040077554-A1 | Indolocarbazole anticancer agents and methods of using same | ADVANCED LIFE SCIENCES, INC. | 2004-04-22 | — | — | US | disclosed |
| EP-1341412-A1 | INDOLOCARBAZOLE ANTICANCER AGENTS AND METHODS OF USING THEM | Advanced Life Sciences, Inc. (US) | 2003-09-10 | — | — | EP | disclosed |
| US-20030087842-A1 | Indolocarbazole anticancer agents and methods of using them | ADVANCED LIFE SCIENCES, INC. | 2003-05-08 | — | — | US | disclosed |
| WO-2002048166-A1 | INDOLOCARBAZOLE ANTICANCER AGENTS AND METHODS OF USING THEM | ADVANCED LIFE SCIENCES, INC. (US) | 2002-06-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040077554-A1 | Indolocarbazole anticancer agents and methods of using same | TOP1, TOP2A, TOP2B | TRPM8 4721/4885KDM4E 2544/4885MAPT 3709/4885 |
| US-20030087842-A1 | Indolocarbazole anticancer agents and methods of using them | TOP1, TOP2A, TOP2B | TRPM8 4783/4885KDM4E 2551/4885MAPT 3822/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.