Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | CES2 | O00748 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | CES1 | P23141 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | AR | P10275 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4281585 | 0.90 | KDM4E (0.40) | KDM4EALDH1A1RAB9ATDP1CES2 | |
| SCHEMBL4281593 | 0.90 | KDM4E (0.40) | KDM4EALDH1A1RAB9ATDP1CES2 | |
| SCHEMBL4281595 | 0.90 | KDM4E (0.40) | KDM4EALDH1A1RAB9ATDP1CES2 | |
| Potassium Ion SCHEMBL5829357 | 0.78 | ALDH1A1 (0.37) | KDM4EALDH1A1RAB9ATDP1SMN1; SMN2 | |
| SCHEMBL4271503 | 0.74 | ALDH1A1 (0.43) | KDM4EALDH1A1RAB9ATDP1SMN1; SMN2 | |
| Potassium Ion SCHEMBL2476667 | 0.69 | KDM4E (0.37) | KDM4EALDH1A1RXFP1SMN1; SMN2LMNA | |
| Potassium Ion SCHEMBL3930244 | 0.69 | MAPT (0.48) | KDM4EALDH1A1RAB9ATDP1SMN1; SMN2 | |
| Potassium Ion SCHEMBL3930246 | 0.69 | MAPT (0.48) | KDM4EALDH1A1RAB9ATDP1SMN1; SMN2 | |
| SCHEMBL4281219 | 0.68 | CYP1A2 (0.39) | KDM4EALDH1A1RAB9ATDP1SMN1; SMN2 | |
| SCHEMBL4281214 | 0.68 | CYP1A2 (0.39) | KDM4EALDH1A1RAB9ATDP1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732566-A2 | 6-AZAINDOLE COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2006-12-20 | — | — | EP | disclosed |
| WO-2005097129-A2 | 6-AZAINDOLE COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2005-10-20 | — | — | WO | disclosed |